GLAS Grant Awards and Recipients


Impact of Environmental Enrichment on Aggression and Welfare in Cichlid Fish
PI: Peter Dijkstra, PhD; Central Michigan University
Co-I: Jon Kelty, PhD

Efficacy of Long-Acting Transdermal Buprenorphine in C57BL/6 Mice
PI: Kathryn Emmer, DVM, MS, DACLAM; The Ohio State University
Co-I: Valerie Bergdall, DVM, DACLAM

Morphine Pharmacokinetics and Pharmacodynamics in Pigs
PI: Stephanie Hon, DVM, DACVAA; Cornell University
Co-I: Jordyn Boesch, DVM, PhD, DACVAA; Cristina de Miguel Garcia, DVM, MSc, MRCVS, DECVAA

Evaluation of the Antimicrobial Effects of Blue Light and Hypochlorous Acid on the Macaque Cranial Implant-Tissue Margin Microbiota
PI: Mia Lieberman, DVM, PhD, DACLAM; Harvard Medical School


A Comparison of LED versus Fluorescent Lighting on Behavior, Stress, and Reproductive Success in Laboratory Zebra Finches (Taeniopygia guttata)
PI: Niora Fabian, MS, DVM; Massachusetts Institute of Technology
Co-I: Alanna Backx, MSc, DVM; Michale S. Fee, PhD

Evaluating the Efficacy and Feasibility of Oral Albendazole and Fumagillin in the Treatment of Pseudoloma neurophilia in Adult Zebrafish (Danio rerio)
PI: Elizabeth Lavin, DVM; Cornell University
Co-I: Erin Daugherity, DVM, MS, DACLAM; Rodman Getchell, MS, PhD; Renata Ivanek, DVM, MS, PhD; Michael Kent, PhD

Mouse Response to Marmoset Odor
PI: Trinka Adamson, MS, DVM, DACLAM; Salk Institute for Biological Studies
Co-I: Erika Wright-McAfee, MLAS, DVM

Refinement of Fur Mite Treatment in Mice Using Ivermectin Diet and PCR Testing
PI: Wai Hanson, DVM, PhD, DACLAM; Emory University
Co-I: Kenneth S. Henderson, MSc, PhD

Standardization of Husbandry Practices in Xenopus laevis Using the Corticosterone Stress Response
PI: Cynthia Lockworth, DVM, DACLAM; University of Texas, MD Anderson Cancer Center

When Good Food Goes Bad: The Impact of Rancidity on Mouse Feeding Behavior and Health
PI: Joshua Cordeira, PhD; Western Connecticut State University
Co-I: Forest Robertson, PhD


Evaluation of the well-being of aging male Sprague Dawley rats in a variety of commercially available individually ventilated caging system
PI: Debra Hickman, MS, DVM, DACLAM, DACAW; Indiana University

Moving Marine Fish Toxicity Tests Towards the 3Rs
PI: Marlo Jeffries, PhD; Texas Christian University
Co-I: Dalton Allen, BS

Evaluating the Effectiveness of a Macaque-Specific Probiotic in Managing Post-Relocation Diarrhea in a Colony of Macaca fascicularis
PI: Keely McGrew, BSc, CVT, LATG, CMAR; Charles River
Co-I: Nicole Monts de Oca, DVM, ACLAM

Handling, Enrichment and Reproduction: the effects of transfer tunnels on the reproductive indices of BALB/c and CD-1 mice
PI: Elizabeth Nunamaker, PhD, DVM, DACLAM, DACAW; PI: Penelope Susan Reynolds, PhD; University of Florida
Co-I: Margaret Anne Hull, MoP, DVM

Effects of LED lighting on fecundity and stress in C57BL/6 mice
PI: Joyce Stuckey, MS, DVM; Rutgers; The State University of New Jersey
Co-I: John Hershey, VMD, PhD


Effect of Genetic Background on Foster Survival Outcomes in Inbred Laboratory Mouse Strains
PI: Natallia Riddick, PhD; University of North Carolina in Chapel Hill

Use of continuous home cage monitoring to determine the impact of cage division on rodent social interactions, aggression, and anxiety behaviors
PI: Molly Klores, VMD; New York University Langone Health (NYU School of Medicine)
Co-I: Adam Mar, PhD; Skye Rasmussen, DVM, DACLAM

Pharmacokinetics of Buprenorphine in Common Marmosets (Callithrix jacchus)
PI: Jennifer Haupt, DVM, DACVS; Massachusetts Institute of Technology
Co-I: Niora Fabian, DVM, MS

Effects of housing density and tank volume on the behavior, cortisol level and neurochemistry of zebrafish: A systematic analysis to optimize zebrafish maintenance.
PI: Robert Gerlai, MSc, PhD; University of Toronto Mississauga
Co-I: Benjamin Tsang, BSc

Characterization of the Pathobiome and Pathogenesis of Clinical Corynebacterium bovis Infections
PI: Christopher Manuel, DVM, PhD, DACLAM; University of Colorado Denver, Anschutz Medical Campus
Co-I: Stephanie Montgomery, DVM, PhD, DACVP; Kourtney Nickerson, PhD; Ken Henderson, PhD, MS


The use of midazolam as an appetite stimulant and anxiolytic in the common marmoset
PI: Jessica Izzi, DVM, MLAS, DACLAM; John Hopkins University School of Medicine
Co-I: Jessica Herrod, DVM; Eric K. Hutchinson, DVM, DACLAM

Evaluation of pain-related behavior and pain sensitivity in disbudded goat kids with corneal nerve block using lidocaine or bupivacaine liposome injectable suspension
PI: Lais de Matos Malavasi, DVM, MSc, PhD; Washington State University College of Veterinary Medicine
Co-I: Jessie Carol Ziegler, BS, MS, DVM

Comparison of Light Emitting Diode Versus Cool White Fluorescent Lighting Exposure in Sprague-Dawley Rats on Circadian Regulation of Physiology and Metabolism
PI: Amy Pierce, MS, RLAT; Tulane University
Co-I: Georgina L. Dobek, DVM, DACLAM

Evaluation of the response of the rat circadian system to vivarium nighttime "safe" red light 
PI: Robert Spencer, PhD; University of Colorado Boulder
Co-I: Jon Reuter, MPVM, DVM, DACLAM

Zebrafish Embryo Disinfection: Refining the Bleaching Protocol 
PI: Adrienne Winn, MAg, DVM; New York University School of Medicine
Co-I: Samantha Peneyra, DVM, DACLAM; Kevin Prestia, DVM, MPH, DACLAM

Mice with Ulcerative Dermatitis Treated versus Untreated, Does it Make a Difference?
PI: Deborah Yoakum, RVT, LATG; La Jolla Institute for Allergy and Immunology
Co-I: Catherine C. Hedrick, PhD; Paola Marcovecchio, MA; Lindsey Padgett, PhD


Characterization of the fecal bacterial microbiota of healthy semi-wild, healthy corralled, and chronic diarrheic corralled rhesus macaques (Macaca mulatta)
PI: Nicole Compo, DVM, DVSc; University of Puerto Rico
Co-I: Diego Gomez-Nieto, MV, MSc, MVSc, PhD, DipACVIM

Daytime Blue-Enriched LED Light Exposure: Influence on Circadian Regulation of Mouse Physiology and Metabolism
PI: Robert Dauchy, MS, CMAR, RLATG; Tulane University School of Medicine
Co-I: David E. Blask, PhD, MD; Steven M. Hill, PhD; Georgina M. Dobek DVM, DACLAM

Effects of enhanced husbandry on stereotypic behavior and experimental variability in a monogamous species of rodent
PI: Natalia Duque-Wilckens, DVM, PhD; University of California, Davis
Co-I: Brian Trainor, MS, PhD

Is subcutaneous administration of buprenorphine effective in rabbits? A study of plasma concentrations after intravenous, subcutaneous and intramuscular injection.
PI: Patricia Hedenqvist, DVM, PhD, DECLAM; Swedish University of Agricultural Sciences
Co-I: Lena Olsén, PhD

Gut Microbiome Alterations in Marmoset Wasting Syndrome
PI: Joseph Mankowski, DVM, PhD, DACVP; John Hopkins University School of Medicine
Co-I: Rachel E. Cooper, DVM, MS; Lisa M. Mangus, DVM, PhD, DACVP; Eric K. Hutchinson, DVM, DACLAM

Exploring cardiovascular and metabolic stress responses to carbon dioxide euthanasia
PI: Kathryn Nichols, MS, SRS; Data Sciences International
Co-I: Megan Swaab Fine, DVM, MS, DACVS-LA; Kimberly Holliday-White BS, SRS; Heather Bogie CVT, SRS, RLATG; Kim Swearingen, CVT, SRS; Jennifer Doyle, BS; Scott Tiesma, BS

Effect of social and single housing on the progression of SIV infection in macaques
PI: Kelly Metcalf Pate, DVM, PhD, DACLAM; John Hopkins University
Co-I: Leah Rubin, MA, PhD, MPH

Pharmacokinetics and Safety of Intramuscular Meloxicam in Zebra Finches (Taeniopygia guttata)
PI: Mary Patterson, MS, DVM, DACLAM; Massachusetts Institute of Technology


Stress Hormone (ACTH) and Behavior Response to Different Euthanasia Methods
PI: Greg Boivin, DVM, MS, MBA, DACLAM; Wright State University

Evaluation of Enclosure Space Utilization in Current Housing Standards in Xenopus laevis
PI: Sean Kelly, VMD; The Rockefeller University
Co-I: Leslie Diaz, DVM, MPH, DACLAM; Ravi Tolwani, DVM, PhD, DACLAM

Alternative Delivery Methods for Post-Operative Analgesia Using Meloxicam in Mice
PI: Angela Mexas, DVM, PhD, Dip ACVIM, Dip ACLAM; Midwestern University
Co-I: Cynthia J. Doane, DVM, DACLAM

Multicentric Evaluation of the Effects of Altitude on Rat Behavioral Research
PI: Jon Reuter, MPVM, DVM, ACLAM; University of Colorado
Co-I: Mathias Leblanc, DVM, ACLAM, PhD; Sean Adams, DVM, ACLAM, PhD; Christopher A. Lowry, PhD

Effect of 405nm Light as a Direct Treatment to the Mammalian Brain
PI: Gordon Roble, DVM, DACLAM; New York University
Co-I: Colleen Thurman, DVM, MS


Targeted Buprenorphine Sustained Release Analgesia Protocol for Guinea Pig Studies
PI: Donald Casebolt, DVM, MPVM, DACLAM; University of Southern California
Co-I: Andrea Zanetti, DVM, MS, PhD, SRS; Sumanth Putta, DVM, MS, PhD, DACLAM; Stan Louie, PharmD

Efficacy of Buprenorphine and Butorphanol in Relieving Pain in a Surgical Model in Axolotls
PI: Tara Cotroneo, DVM, DACLAM; Wayne State University
Co-I: Gerald Hish, DVM, DACLAM; Jeremy Llaniguez, MS

Assessing CO2 Euthanasia and Intracoelomic Ethanol Overdose in Avian Species
PI: Erin Daugherity, MS, DVM, DACLAM; Cornell University
Co-I: Amy Rizzo, DVM; Wendy Williams, DVM, DACLAM; Luce Guanzini, BS, LATG

Development of an Efficient and Effective Protocol for Playfully Handling Rats
PI: Brianna Gaskill, PhD; Purdue University
Co-I: Sylvie Cloutier, PhD; Marguerite O'Haire, PhD; Megan LaFollette, BS

Optimizing the Evaluation of Animal Welfare in the Murine Model of Ulcerative Colitis
PI: Jessica Lang, BSc, BUS, RLATG, CM; University of Miami
Co-I: Maria Abreu, MD; Julia Zaias, DVM, PhD, DACLAM

Transmission of MPV in Rodent Feed
PI: Mathias Leblanc, DVM, PhD, DACLAM; The Salk Institute for Biological Studies
Co-I: Jon Reuter, DVM, MPVM, DACLAM; Robert Livingston, DVM, PhD, DACLAM; Matthew Myles, DVM, PhD, DACLAM; Carrie Schultz, PhD

Novel Cage-side Assessments of Post-Operative Pain in Mice
PI: Jennifer Lofgren, MS, DVM, DACLAM; University of Michigan

Impact of Animal Caging on Physical Performance in Mice
PI: Kenneth Seldeen, PhD; University at Buffalo
Co-I: Bruce Troen, MD

Pharmacokinetics of Intraperitoneal and Subcutaneous Nalbuphine in Mice
PI: Douglas Taylor, DVM, MS, DACLAM; Emory University
Co-I: Bo Wen, PhD


CO2 Comparison of Physiologic Responses to Different Mouse Euthanasia Methods
PI: Greg Boivin, DVM, MS, DACLAM; Wright State University
Co-I: Nadja Grobe, PhD

Murine Astrovirus Detection
PI: Susan R Compton, PhD; Yale University School of Medicine
Co-I: James D Macy, DVM, PhD, DACLAM

Towards the 3Rs in Fish Toxicity Testing
PI: Marlo K Jeffries, PhD; Texas Christian University

The Gastrointestinal Side Effects of Buprenorphine in Rabbits and a Possible Antidote
PI: Manuel Martin-Flores, DVM, DACVAA; Cornell University College of Veterinary Science
Co-I: Robin D Gleed, BVSc, MA, DipECVAA, DACVAA, MRCVS

The Use of Operant Measure to Assess Duration of Action of Opioid Analgesics in Rats
PI: Harvey E Ramirez, DVM, DACLAM; University of Florida


CO2 Concentration for Mouse Euthanasia
PI: Greg Boivin, DVM, MS, DACLAM; Wright State University
Co-I: Nadja Grobe, PhD

Use of Novel Automated Feeders to Control Obesity of Socially-housed Rhesus Macaques
PI: Kelly F Ethun, DVM, PhD; Yerkes Primate Research Center
Co-I: Zachary P Johnson, PhD; Mark E Wilson, PhD

Evaluating Analgesic Efficacy for Post-Operative Pain in Male Guinea Pigs
Jennifer Lofgren, DVM, MS, DACLAM; University of Michigan Medical School
Co-I: Jean Nemzek, DVM, MS, DACVS

Biological Validation of Hair Corticosterone as a Biomarker of Chronic Stress in Rats
PI: Fabrizio Scorrano, DVM, PhD; Universitat Autónoma de Barcelona
Co-I: Antonio Armario, PhD

Comparison of Firocoxib, Meloxicam, and Buprenorphine Analgesia in Rats
PI: Bhupinder Singh, BVSc & AH, MVSc, DACLAM; Cornell University

A Minimally Invasive Electroencephalographic Procedure for Rats
PI: Christopher P Ward, PhD; University of Houston-Clear Lake


Pharmokinetics of Ceftiofur (Excede®) in Rhesus Macaques (Macaca mulatta)
PI: Kari Christe, DVM, DACLAM; University of California, Davis
Co‐I: Gregory Salyards, DVM

Efficacy of Pathogen Removal by Cage Washing and Dump Station Testing for Pathogens
PI: Susan R Compton, PhD; Yale University School of Medicine
Co‐I: James D Macy, DVM, DACLAM

Effectiveness and Safety of NonOpioid Analgesics in a Rainbow Trout Surgical Model
PI: Mary Martin DVM, MPH, DACLAM; Cornell University
Co‐I: Paul Bowser, PhD

Evaluation of 21% O2 versus 100% O2 for Isoflurane Delivery to Rodents
PI: Jean Nemzek, DVM, MS, DACVS; University of Michigan
Co‐I: Laura Wilding, DVM, PhD; Krishnan Raghavendran, MD

Effect of Changes in Housing Environment on Platelet Activation in Macaques
PI: Kelly Pate, DVM, PhD, DACLAM; Johns Hopkins School of Medicine
Co‐I: Kenneth Witwer, PhD


Maternal Weight Gain as a Predictor of Litter Size in Three Mouse Strains
PI: James Finlay, DVM; City of Hope/Beckman Research Institute
Co‐I: Trinka Adamson, MS, DVM, DACLAM

Optimizing Zebrafish Reproduction Through Advancements in Feeding
PI: John Gonzales, RLATG, MS; National Institute of Child Health and Human Development, National Institutes of Health
Co‐I: Igor Dawid, PhD

Impact of Ventilated Caging on Water Intake and Loss in Four Strains of Laboratory Mouse
PI: Judy Hickman‐Davis, DVM, PhD; The Ohio State University
Co‐I: Valerie Bergdall, DVM

Efficacy of Tramadol Analgesia in Murine Models of Inflammation and Sepsis
PI: Jean Nemzek, DVM, MS, DACVS; University of Michigan

The Effects of Vibration in Mouse Physiology
PI: John Norton, DVM, PhD, DACLAM, DABT; Duke University Medical Center
Co‐Is: Daniel Schmitt, PhD; Randall Reynolds, DVM, MS DACLAM

Inducing Lactation in the NonPregnant African Green Monkey
PI: Shannon Smith, DVM; Duke University
Co‐I: Sallie Permar, MD/PhD

Behavioral Impact of Housing Density and Ambient Temperature in Mice
PI: Linda Toth, DVM, PhD; Southern Illinois University School of Medicine

Acute Phase Proteins as Markers of Mouse Transport Stress
Julia Zaias, DVM, PhD, DACLAM; University of Miami
Co–I: Carolyn Cray, PhD


Effect of IVC Hypercapnic and Hypoxic Conditions on Mouse Development
PI: Claude M Nagamine, DVM, PhD, DACLAM; Stanford University

Effects of Blood Collection on Clinically Ill Mice in Biomedical Research
PI: James Marx, DVM, PhD, DACLAM; University of Pennsylvania
Co‐Is: F Claire Hankenson DVM, MS, DACLAM; JanLee Jensen DVM, DACLAM, DACVIM

Impact of Larval Diet on Zebrafish Growth and Fecundity
PI: Deborah Yelon, PhD; University of California, San Diego

Pharmacokinetics of Buprenorphine in Nonhuman Primates
PI: Elizabeth A Nunamaker, PhD, DVM; University of Illinois at Chicago
Co‐Is: Lisa Halliday, DVM; David Moody, PhD

Pharmacokinetics and Efficacy of Oral Meloxicam and Carprofen in Mice
PI: Patricia V Turner, BSc, MS, DVM, DVSc, DACLAM, DABT; University of Guelph
Co‐Is: Marcus Litman, BSc, DVM, Dip LAS; Ron Johnson, DVM, PhD, DACVCP

The Use of Operant Measures to Evaluate Analgesic Efficacy in Rodents
PI: Harvey E Ramirez, DVM, DACLAM; University of Florida
Co‐I: John K Neubert DDS, PhD


Does Increased Cage Space Reduce Abnormal Behavior in Adult Macaques?
PI: Babette M. Fontenot, DVM, PhD, DACLAM; University of Louisiana at Lafayette New Iberia Research Center

Effect of Pain Management on Immunization Efficacy
PI: Laura P Hale, MD, PhD; Duke University Medical Center
Co‐Is: April Kolstad, DVM; Herman Staats, PhD

Evaluation of Risk Factors for Mouse Parvovirus Transmission
PI: Susan R Compton, PhD; Yale University School of Medicine

A Measurement of Stress Levels in Mice Housed in the Same Room with Rats
PIs: Chrystal L Redding, MS, RLATG; Thomas M Greene, BS, RLAT; Northern Arizona University
Co‐I: Melissa Birkett, PhD

Monitoring Laboratory Rat WellBeing Using Ultrasonic Vocalizations
PI: Sylvie Cloutier, MS, PhD; Washington State University
Co‐Is: Ruth C Newberry, PhD; Jaak Panksepp, PhD


Behavioral and Neurobiological Effects of Communal Nesting in Inbred Mice
PI: Kathleen Heiderstadt, DVM, MS, DACLAM; Pennsylvania State University
Co‐Is: David A. Blizard, BA, PhD; David J Vandenbergh, BS, PhD; Igor Branchi, PhD; Jacqueline N Crawley, PhD

The Impact of Nesting Material on Behavior in Isolated or Group Housed C57Bl/6 Mice
PI: Kathy Laber DVM, MS, DACLAM; Medical University of South Carolina
Co‐I: Marcelo Lopez, PhD

Physiological and Behavioral Effects of Environmental Vibration in Mice
PI: Aaron L. Olsen, DVM, PhD; Utah State University
Co‐Is: Steven Folkman, PhD; Timothy Shahan, PhD

Post‐Operative Analgesia in a Mouse Mammary Cancer Model
PI: Trinka W. Adamson, BHS, MS, DVM; University of California, Davis
Co‐I: Alexander D Borowsky, BS, MD

Superovulation of Six Commonly Used Mouse Strains Determined by Weight
PI: Jan Parker‐Thornburg, PhD; MD Anderson Cancer Center
Co‐Is: Charlie (Zhezong) Luo, MD; Juliana Zuniga, BS

The Use of Nesting Behavior for Pain Scoring and Determination of the Effect of Nesting Material Provision on PostOperative Fecal Corticosterone Levels in Mice
PI: Douglas K Taylor, DVM, MS, DACLAM; Emory University
Co‐I: Patricia Whitten, PhD


The Effect of Cage Conditions and Group Size on Rat Wellbeing and Affective State
PI: Patricia V Turner, MS, DVM, DVSc, DACLAM; University of Guelph
Co‐I: Francesco Leri, PhD

Impact of Nesting Material on Mouse Thermoregulation and Variability
PI: Joseph P. Garner, PhD; Purdue University
Co‐Is: Jerry K Davis DVM, PhD; Christopher J. Gordon, PhD

Use of Cognitive Bias to Assess Welfare of Rats Housed in Cages with Altered Dimensions
PI: Deb Hickman, DVM, MS, DACLAM; Portland VA Research Foundation
Co‐I: Stephanie Murphy, VMD, PhD, DACLAM


Animal Darkphase Light Contamination: Impact on Human Cancer Metabolism
PI: Robert T Dauchy, BA, RLATG; Bassett Research Institute
Co‐I: David E. Blask, PhD, MD; Michael Greene, PhD

Characterization of Body Condition Score as a Method of Assessing Health Status in Rats
PI: Deb Hickman, DVM, MS, DACLAM; Portland VA Research Foundation
Co‐I: Stephanie Murphy, VMD, PhD, DACLAM; Sharon Anderson, MD

Determination of the Appropriate Ambient Temperature for Housing Small Rodents
PI: Lisa Leon, PhD; US Army Res Inst, Natick, MA
Co‐I: Justin W. Brown, PhD

Positive Human Contact as Social Enrichment to Improve Rat Welfare and Research Validity
PI: Sylvie Cloutier, BSc, MSc, PhD; Washington State University
Co‐Is: Ruth Newberry, PhD; Jaak Panksepp, PhD