Sunday, October 28

Technical Trade Presentations Track 1: Innovations and Technical Advancements

Vetcorder: Patient Monitoring in the Palm of Your Hand!

1:00 PM - 1:20 PM/Room: 343
Speaker: David B Brunson
Moderator: Robert Young

The Vetcorder is a Bluetooth-enabled vital signs monitor for physiologic animal assessment, especially useful in the perianesthetic or perioperative period. The novel Vetcorder enables heart rate monitoring, electrocardiography (ECG), and pulse oximetry (SpO2) via a small instrument the size of a deck of cards. The Vetcorder can transmit the vital organ information via Bluetooth to a remote (nonattached) display to enable assessment of the animal remotely. Monitor measures can be used to assess cardiac rhythm and heart rate, pulse rate, hemoglobin oxygen saturation (SpO2), and temperature. These indices may provide professionals with insights into the patient’s depth of anesthesia and adequacy of analgesia, as well as cardiac and respiratory function. The device and uniquely adapted needle electrodes have been used successfully in many species, including primates, rodents, lagomorphs, canids, felids, swine, and horses and cattle, among others.

This Technical Trade Presentation is sponsored in part by Sentier Connect LLC.

Oxygen Concentrators: A Good Idea for Inhalation Anesthesia?

1:20 PM - 1:40 PM/Room: 343
Speaker: Robert "Bob" Schrock
Moderator: Carrie Schultz

Inhalation anesthesia systems have traditionally been used with 100% oxygen being delivered from tanks or central supplies. Recent advances have led to the use of oxygen concentrators instead. We will explore the nature of these units and determine if it may be a good fit for your lab or your facility. We will discuss how such a device is possible, how it may or may not be compatible with your anesthesia system, and most importantly, how it might affect your research studies. Tangential benefits include significant cost savings; elimination for the need to change, order, and store tanks; plus the greatest advantage of all, the elimination of potential pathogens making their way into your facility on a rented O2 tank.

This Technical Trade Presentation is sponsored in part by VetEquip Inc.

Can I Really Deliver Isoflurane Without Using Compressed Gas?

1:40 PM - 2:00 PM/Room: 343
Speaker: Dave FitzMiller
Moderator: Carrie Schultz

Yes, the most common method for delivering inhalant anesthesia, such as isoflurane, employs traditional canister-style instruments that use a mechanical vaporizer to mix the liquid anesthetic chemical with compressed oxygen at a prescribed ratio to produce the proper anesthetic gas mixture. In recent years, technical improvements on how we deliver inhalant anesthetics have been made, and alternative systems provide researchers with more options, one of which is the ability to deliver isoflurane without the need for using compressed gas. In this presentation, you will learn about how you and your lab can deliver isoflurane without compressed gas, use less isoflurane, and improve researcher safety. If you work with rodents and isoflurane, you will not want to miss this presentation.

This Technical Trade Presentation is sponsored in part by Kent Scientific Corporation.

The Janet Wood Innovation Award—A Global Initiative to Invent and Introduce Novel Enrichment

2:00 PM - 2:20 PM/Room: 343
Speaker: Nicky Windows
Moderator: Carrie Schultz

Since it's conception in 2016, the Janet Wood Innovation Award has successfully launched more than 6 products into the global marketplace. These products were designed by animal technicians. From entering a competition with a concept product, the winners are selected by a panel of judges and the winning entries are taken from concept to marketplace with the help of the Datesand team. Entering a design can be a daunting prospect, but this presentation aims to dampen any fears and show how a sketched concept can be turned into a commercially available product which can then have a positive impact on animal welfare around the world.

This Technical Trade Presentation is sponsored in part by Datesand Ltd.

Leveraging the Power of Video Technology and Computer Vision to Improve in Vivo Studies

2:20 PM - 2:40 PM/Room: 343
Speaker: Laura Schaevitz
Moderator: Carrie Schultz

The use of video technology inside the vivarium to monitor in vivo studies is one of the most rapidly growing areas of innovation in animal model research. Specifically, the ability to record subject video 24/7 in a noninvasive, home-cage specific manner has created the possibilities for a wide variety of new retrospective, real-time, and predictive analyses. When combined with the rapid advances in computer vision technology across wide-ranging industries outside of pharma, subject video is proving to quickly become the basis for how all study analysis and data insight will be generated in the future. This session will examine some of the groundbreaking ways video and computer vision is being utilized in traditional and experimental animal models to provide new, more accurate, and more translational study results.

This Technical Trade Presentation is sponsored in part by Vium.

Using 3D Scanning to Standardize the Measurement of Subcutaneous Tumors
2:40 PM - 3:00 PM/Room: 343
Speaker: Andrew Smith

Moderator: Juan Delgado

For decades handheld calipers have been used to measure the volume of subcutaneous tumors in mice in preclinical oncology research. Yet research shows their use can result in operator and inter-operator bias and more mice being used for repeat studies due to data inaccuracies. Ultimately, this increases the cost and slows down the development of drug therapies. With pressure increasing from regulatory bodies to improve research standards and animal welfare, pharmaceutical companies, CROs, and academic institutions are turning to 3D scanning to deliver improved results in tumor measurement and to advance global oncology research. This presentation looks at why calipers are not the optimum tool to carry out tumor measurements and the benefits of using 3D scanning instead, including more precise and consistent measurements, full transparency and traceability, greater welfare in adherence with the 3Rs, and workflow optimization. We will showcase the improved results already being achieved by laboratories in the EU and USA using the BioVolume high-precision 3D scanning and measurement system. This session is ideally suited to laboratory animal scientists, veterinarians, technicians, and managers working in preclinical oncology research.

This Technical Trade Presentation is sponsored in part by Fuel3D.

A New Tool for Oncology Researchers: The Rag2/IL2RG (R2G2) Knockout Mouse

3:00 PM - 3:20 PM/Room: 343
Speaker: Sheri J Wildt
Moderator: Jamie Naden

Immunodeficient mouse models have been instrumental in the advancement of oncology research in the past several decades. The R2G2 mouse model, developed at Fox Chase Cancer Center, is one of the newest commercially available double-knockout mouse models with an ultra immunodeficient phenotype. This model was created by backcrossing the IL2RG (common gamma chain) mutation on to mouse with a mutation in Rag2. The recombination activating gene 2 (Rag2) knockout causes a deficiency in T and B cells. The common gamma chain gene (IL2RG) interruption results in a lack of functional receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. R2G2 mice have several unique features that translate into unique benefits as compared to other immunodeficient models, including higher tolerability to radiation, estrogen pellet supplementation, and some chemotherapeutic agents. We will present the unique characteristic of this new mouse model and how to use them to leverage your oncology or immunology research program.

This Technical Trade Presentation is sponsored in part by ENVIGO.

Use of Automated Sampling to Get Better Data from Fewer Animals

3:20 PM - 3:40 PM/Room: 343
Speaker: Candace Rohde-Johnson
Moderator: Shelly Carballo

More than 70% of researchers have tried and failed to reproduce another scientist's experiments, and more than half have failed to reproduce their own experiments. In this session, we’ll review some potential causes of these issues, and examine both the things you can see: staff, material, and technique differences, as well as the things we can’t always see: stress, individual animal variability, and the effects of dosing and sampling method on results. We’ll further explore the application of automated dosing and sampling as a means to improve animal welfare and data integrity while reducing human intervention. There is a surprising effect of stress on drug absorption and distribution; automation has the potential to reduce these confounding effects, reduce animal usage and ultimately to reduce re-work and repeats. This session will be most beneficial for researchers performing compound dosing studies for PK/PD, but will have relevance to any animal researchers interested in the effects of humans on animal studies.

This Technical Trade Presentation is sponsored in part by BASi.

Impact of Extrusion on Bioburden in Laboratory Animal Diets

3:40 PM - 4:00 PM/Room: 343
Speaker: Laura N Tracey
Moderator: Carrie Schultz

Extrusion has historically been the manufacturing method of choice for diets for many species in biomedical research, including nonhuman primates, cats, and dogs. Originally, extrusion was used mostly for digestion benefits of these species; however, over the last decade, extruded products have become increasingly popular choices for other species (rodents) for other reasons. Reduction of bioburden is one sometimes purported advantage of extrusion over pelleting, based on the fact that the extrusion process involves steam and temperature levels great enough to kill many microorganisms. This talk will discuss the steps of the extrusion process, including common temperatures reached and time at those temperatures. Also discussed will be post-extrusion steps that may impact the overall microbial load on the finished product. This information may be used by facility managers and researchers to determine if using extruded product without irradiation might be an appropriate option for your facility.

This Technical Trade Presentation is sponsored in part by PMI Nutrition International (LabDiet®).

Technical Trade Presentations Track 2: Developments in Facility Management

An IVC for Environmentally Conscious Facilities

1:00 PM - 1:20 PM/Room: 341
Speaker: Liz Kramer
Moderator: John A Park

Research operations come at an incredible environmental cost from things such as sterilization, disposable PPE, equipment power demands, waste streams, and even recyclable products. Can we as a research community reduce the stress our industry places on the environment? It is possible to make environmental considerations a priority, and this presentation will demonstrate the economic advantages of doing so. Even when using ventilated caging, you can reduce the carbon footprint of your facility while making the best use of your equipment, people, and budgets. Certain innovations in caging and sensor technologies can deliver ideal environments for your animals and improved working conditions for your personnel, while saving enormous amounts of money and reducing the environmental impact of daily operations. We all breathe the same air, drink the same water, and live on the same planet. It is time to prioritize our common global resources and as a scientific research community, we can lead the way. The speaker was a full-time environmental activist before joining Lenderking. Her talk will include framing the environmental challenge through her time as a pick-up artist on the nonprofit project Pick Up America, which walked across the country and picked up 100 tons of roadside litter. She is passionate about good science and creating a greener future. She joined the Lenderking team because it allows her to do both.

This Technical Trade Presentation is sponsored in part by Lenderking Caging Products.

Are Your Studies Reproducible?

1:20 PM - 1:40 PM/Room: 341
Speaker: Preben Leonhardt
Moderator: John A Park

Yearly, $28,000,000,000 are wasted on nonreproducible animal studies in the U.S. This presentation will estimate the cost for a single university/vivarium for studies which might be spent in vain. One important parameter which might not always be in full control is the relative air humidity, which is well known to have an influence on animal welfare. During this presentation we will discuss how it may also affect reproducibility of animal research. We ask the question, “is compliance with guidelines specifying 30-70% relative humidity good enough, or would a much more accurate adjustment of relative humidity be required to enhance reproducibility of research?” Studies looking at water intake, food consumption, and activity level at different humidity levels will be presented and experiences on how it may affect studies on metabolism, diabetes, respiratory systems, sensory organs, mental disorders, behavior, or even breeding will be shared.

This Technical Trade Presentation is sponsored in part by Scanbur A/S.

Operating Next-Generation Animal Facilities in the Age of Big Data

1:40 PM - 2:00 PM/Room: 341
Speaker: Terry R Coley
Moderator: John A Park

Leading institutions are taking a top-down view of core facilities to understand how to operate most efficiently and best serve the needs of researchers. Using examples from the City of Hope and the University of British Columbia, we will show provosts, facility managers, directors of operations, and veterinary directors concrete examples of how real-time animal facility data collection, combined with key human resources, can create continuous improvement in the animal facility. As expected, part of the solution involves using software to replace paper-based processes. Achieving further improvement requires facilities to consider human resources and software that goes beyond traditional point-solutions for cage cost recovery and IACUC document management. By implementing real-time data collection software, animal facilities generate a treasure trove of operational data that serves as fuel for improving efficiency. If data is the fuel, then the facility data analyst (a role often missing) is the engine needed to drive improvement. Transparent access to appropriate facility data also provides a rich, value-added service for research groups. Researcher/facility communication is improved, confidence in data integrity is heightened, and researchers can easily see how to optimize their lab animal resources.

This Technical Trade Presentation is sponsored in part by Virtual Chemistry Inc.

Digitalization in the Animal House—How to Bridge the Gap into the Animal Room

2:00 PM - 2:20 PM/Room: 341
Speaker: Stephan E Hammelbacher
Moderator: John A Park

This talk will cover the status of digitalization in the animal house and analyze the blank areas in the animal room. The Internet of Things (IoT) is an important means to control data and to support the daily work in the animal room. The participants will learn the benefits of integrating the IoT into the animal room by the means of electronic cage cards. Electronic cage cards are electronic cage labels replacing cage cards written or printed on paper. These allow the automated tracking of cages through the animal facility. Once assigned to the cage number of the animal management system and to the cage itself they permit touchless updates of cage information normally protocolled on paper cage cards. This presentation addresses the designers of animal houses, IT process analyzers, and workflow specialists of the animal house.

This Technical Trade Presentation is sponsored in part by Galilei Software GmbH.

Internet of Things (IoT) Technologies Improve Animal Laboratory Management and Research

2:20 PM - 2:40 PM/Room: 341
Speaker: Charles Donnelly
Moderator: Julie Morrison

New approaches to improve laboratory animal welfare, as well as more capable and cost-effective husbandry techniques and data management, are high priorities to the NIH. The technology revolution is changing how humans interact with and analyze the physical world. Computer controlled automation, robotics, sensors, and artificial intelligence are disrupting how work is conducted in all industries. The rate of new technology inventions capable of driving operational efficiencies, reducing research animal use, and increasing experimental reproducibility in research labs continues to accelerate. The Internet of Things (IoT) is one of the key components of the technology revolution. Interacting with the physical world and communicating with the cloud, IoT devices can monitor anything that can be measured from environmental conditions to animal physiology, and they can make real-time decisions that control machines and robots. For animal sciences, IoT devices are emerging as powerful tools for reducing animal stress and research costs while improving experimental reproducibility and accelerating discovery. New energy efficient IoT sensor devices can run for years on a single battery streaming information to the cloud where artificial intelligence algorithms can analyze data and trigger alerts. Researchers can now use these data to correlate IoT measurements with scientific results and facility managers can improve operations with data-driven vivarium workflows. IoT devices that measure light, noise, temperature, humidity, and ammonia levels connected to IoT enabled data management platforms are now commercially available. Here we discuss how scalable cloud IoT solutions for researchers and facility managers are poised to have a transformative impact on both lab animal science and operations.

This Technical Trade Presentation is sponsored in part by RockStep Solutions.

Solving the Pain of Facility Scheduling Using Industry-Specific Software Solution

2:40 PM - 3:00 PM/Room: 341
Speaker: Miki Fontes
Moderator: John A Park

Managing animal facility resources effectively and efficiently can be a challenge. NTM's strategic planning group conducted extensive research and interviews with private organizations and academic institutions. Based on findings, schedulers are spending an inordinate amount of time manually producing daily staff schedules and reviewing daily progress. Husbandry staff relies on room sheets for daily work assignments. Reacting to daily events such as callouts and understanding resource availability is challenging. This process is typically paper-driven, assisted with tools such as Excel spreadsheets or commercial systems not designed for animal facilities. Participants will gain insights on the benefits of automating the entire workflow of their facility staff scheduling, and will come away with understanding 1) the advantages of using a web-based staff scheduling solution to improve process efficiency, create transparency, and provide management with overall status reporting, resulting in cost savings and better animal care and 2) the benefits of implementing industry-specific staff scheduling solutions versus adapting scheduling systems designed for other industries. The target audience includes facility directors, research facility managers, operations managers, and facility supervisors.

This Technical Trade Presentation is sponsored in part by NTM Consulting Services Inc.

How to Incorporate Environmental Diagnostics into Animal Health Monitoring Programs

3:00 PM - 3:20 PM/Room: 341
Speaker: Cindy L Besch-Williford
Moderator: Matthew H Myles

Use of environmental diagnostics (EDx) complements the breadth of testing approaches used to screen for infectious diseases in research rodent colonies. Environmental monitoring involves sampling at the cage, rack, and occasionally room level, and provides information complementary to that collected by other monitoring practices used in quarantine and colony animal surveillance programs. In this presentation, we’ll discuss the various types of EDx sample types and application of EDx monitoring with comparisons to other animal-based sampling approaches. Additionally, examples of how to interpret and confirm results will be provided to facilitate adaptation of these methods to institutional health monitoring programs. The target audience includes veterinarians, facility managers, and technical personnel who manage health monitoring programs.

This Technical Trade Presentation is sponsored in part by IDEXX BioResearch.

Lab and Animal Transfer Station Decontamination in One Simple Step

3:20 PM - 3:40 PM/Room: 341
Speaker: Frances M Grinstead
Moderator: Rich Mullen

Laboratory and animal transfer station (ATS) decontamination pose many challenges. When these areas are decontaminated separately, cross-contamination from one space to the other may occur. Caustic chemical systems are typically used when treating these areas, potentially exposing staff and sensitive equipment to dangerous concentrations of these solutions. While lower concentration aerosols are well-documented to achieve spore sterilization in sealed spaces, their efficacy within the HEPA filters of an ATS were unknown and therefore prompted further examination. Is there a safer, yet effective method of simultaneous decontamination? ”CURIS® System recently collaborated with The Baker Company, a manufacturer of biological safety cabinets, to study the effectiveness of enhanced aerosolized hydrogen peroxide (AHP) technology. Test results showed that AHP via CURIS® Pulse technology is a safe and effective solution to the challenge of simultaneous decontamination with repeatable results over 6 tests and 184 spore carriers. Participants will learn about the Micron Mist™ Technology used in the study, and how the advanced features, including primary injection phase and secondary Pulse injection phase, maximize efficacy and maintain optimal hydrogen peroxide concentration. We will examine the perceived challenges and the results of performing simultaneous decontamination in the presence of an ATS filter. Participants will understand processes that lead to successful 6-log reduction of a spore in the most challenging locations within each environment. Discover how the CURIS® dual injection phases are key to achieving spore inactivation with CURoxide™, a low concentration 7% hydrogen peroxide. This presentation is helpful for lab/facility/operations managers, health and safety managers, and study/research directors.

This Technical Trade Presentation is sponsored in part by CURIS® System.

Principles of Chemical Surface Disinfectant Formulation—What the Laboratory Animal Scientist Needs to Know

3:40 PM - 4:00 PM/Room: 341
Speaker: Jose A Ramirez
Moderator: John A Park

Chemical surface disinfectants (CSD) are a key element of the biosecurity program in animal research labs and breeding facilities. While biocidal efficacy and spectrum of activity are arguably the main factors in CSD selection, other factors are being increasingly taken into consideration. These factors include safety profile, effects on animals, compatibility with surface materials, simplicity and ease of use, environmental profile, and ease of disposal. By incorporating well-known biocidal actives into a multi-component matrix, it is possible to enhance desired properties of an antimicrobial compound while minimizing other unfavorable traits. We will cover the basics of CSD formulation and how this affects the evaluation, testing, and selection process. We will review the different biocidal actives and classes of chemically functional materials that are employed in commercial formulations. Since the regulatory environment may lag behind the needs and expectations of animal research facilities, many animal scientists perform their own product testing and evaluations. We examine how a better understanding of the chemistry of formulations helps the laboratory animal scientist improve the design of testing and evaluation protocols. Participants will learn about the different biocidal actives; why some are preferred over others in a given situation; the basic concepts in formulation of CSDs, including the types and roles of different functional chemicals; understand how the type of formulation affects its testing and evaluation prior to adoption; and how chemical formulations interact with application methods and protocols to impact efficacy, safety, effect on animals and other key performance characteristics.

This Technical Trade Presentation is sponsored in part by Lighthouse Healthcare Partners.

Dry Heat Sterilization for Vivarium Use

4:00 PM - 4:20 PM/Room: 341
Speaker: Robert Davis
Moderator: Denny Mendler

The use of dry heat sterilizers to sterilize laboratory animal cages is becoming more and more prevalent. The purpose of this talk is to educate attendees on use of dry heat in laboratory animal facilities. Topics covered include the origins of dry heat sterilization and its application in lab animal sciences, such as how it works with laboratory animal cages and IVC racks, as well as how the dry heat sterilizer is configured and validated. Additionally, the benefits of dry heat sterilization and how it compares to steam sterilization will be discussed, along with recent case studies.

This Technical Trade Presentation is sponsored in part by Gruenberg-TPS.