Sunday, October 13

Technical Trade Presentations
Track I: Capitalizing Data Technology


Facilitating Better Management and Better Research with Digital Enterprise Colony Management Solutions

1:00 PM - 1:20 PM/Room: 205
Speaker: Anne Gath and Derrick Cheng
Moderator: Amanda Coldwell

This talk will cover the advantages of moving to an enterprise solution for managing animal colony data. Although many animal resource centers are already using a digital solution for colony management, researchers may not have access or use their own solution for managing their animals. With an enterprise solution, researchers can digitally access real-time cage and animal information and submit a variety of electronic service requests. Using different access levels designated by the facility manager, many tasks can be completed within research labs while interfaced with the main animal facility. An interactive model streamlines many processes and saves precious time and resources for both researchers and facility staff. Researchers, technicians, veterinarians, and facility staff can improve processes and communication with interactive modules such as billing, medical records, cage census, and more. An enterprise solution improves communication, generates accurate data, and reduces the cost of labor and supplies, thus generating more revenue for animal resource centers.

This Technical Trade Presentation is sponsored in part by BioInfoRx, Inc.


The Missing Link to Improving Efficiency and Productivity in the Digital Lab
1:20 PM - 1:40 PM/Room: 205
Speaker: Jay Campbell, Paul Donohoe
Moderator: Eric Arlund

The research industry is facing a growing problem—lack of trust within data. Across all phases of research and development, data is at increasing risk of human error, often lacks contextual insight, and can be lost through archaic collection methods. In this presentation, the speakers share an innovative strategy to tackle this challenge with insights on how companies are succeeding in this battle. Key takeaways include understanding why digitalization is at the heart of the smart lab, how to move beyond archaic data collection to gather smart and contextual information; and a case study on how RFID tagging can lead to superior data quality and connectivity.

This Technical Trade Presentation is sponsored in part by Somark Innovations.


Unlock Operating Efficiency with Better Cage Change Processes and Digital Technology
1:40 PM - 2:00 PM/Room: 205
Speaker: Jon Ledford
Moderator: Pat Guider

Versatile and adaptable individual ventilated Caging (IVC) offerings and digital technology advances are set to streamline cage-changing processes and pave the way for improved animal facility operation at multiple levels. Jon Ledford illustrates how data-driven cage-change intervals and individual cage-change methods (partially/just the bottoms, or integrally/full cage) can streamline SOPs and processes. He will examine the pros and cons of different solutions and how intracage monitoring technologies will take efficiency to the next level. He will extrapolate streamlined process data to illustrate the full impact on improved space utilization, reduced risk of cross-contamination, and more.

This Technical Trade Presentation is sponsored in part by Tecniplast.


Improving Animal Model Research by Making Data Fly In-Formation
2:00 PM - 2:20 PM/Room: 205
Speaker: Chuck Donnelly
Moderator: Julie Morrison

Data scientists often spend up to 80% of their time wrangling data. While the data generated from one study could often be reused and lead to new discoveries, they are often not findable. In spite of their value, data are often stored in share folders or dis-integrated databases where they are siloed and lie fallow because they are nearly impossible to search and reuse. Fractured data environments also inhibit analytical strategies, decrease security, and ultimately place a drag on ROI. Like the jets flying In-Formation, the power and value of scientific data is enhanced when data fly in formation. The speaker will challenge the status quo and ask the audience to imagine a research lab where precision informatics tools are deployed to manage laboratory operations and data from the animal room to the scientist’s desktop. The speaker will discuss how the cloud and the edge, with IoT, artificial intelligence, and machine learning, are transforming research, enabling science, accelerating discovery, and improving ROI. With emerging technologies, researchers can regain control of their data, obtain new insights from existing data, and improve lab operational efficiencies, and ultimately accelerate discovery. The speaker will present some of the ideas and technologies available and we caution about some potential pitfalls to watch out for to help you improve your animal lab research as you embark on your journey toward digital transformation.

This Technical Trade Presentation is sponsored in part by RockStep Solutions.


Improved Study Workflows and Animal Welfare through the Use of Digital Biomarkers
2:20 PM - 2:40 PM/Room: 205
Speaker: Laura Schaevitz
Moderator: Pat Guider

Sensor technology is increasingly being used inside the vivarium to allow monitoring of the facility and environment, but also enabling noninvasive continuous collection of behavioral and physiological biomarker data from the animals themselves. Combining digital biomarkers with rapid advances in real-time machine learning and predictive analysis of preclinical big data, enables new study workflows that both improve scientific study outcomes and animal welfare. This session will examine a number of topics, including how digital data can be used to create specifications around normal animals prior to study start, improve randomization, design adaptive studies to reduce animal numbers, and creation of algorithms to alert on unhealthy animals to reduce dead animals.

This Technical Trade Presentation is sponsored in part by Vium Inc.


Adding Dough to the Raisins Makes a Cake—Connecting Best of Breed Technologies to Increase Efficiency and Reduce Risks
2:40 PM - 3:00 PM/Room: 205
Speaker: Andreas Staubi
Moderator: J Patrick Guider Jr

Organizations can pick their "technology raisins" from a wide range of products for all areas of their operations to increase efficiency, reduce costs and risks, and increase data integrity. Additionally, many technologies exist for environmental monitoring, tracking cages, managing inventories, identifying animals, replacing cage cards, and managing training and financial data. This presentation provides insight into how organizations can greatly benefit from using the best fit-for-purpose technologies in a connected, integrated way. We'll demonstrate this approach using the example of tick@lab, a-tune's compliance and lab animal research software suite that inter-operates with other laboratory animal science vendors. We will explain the prerequisites and requirements for creating an integrated technology landscape—forming the perfect cake from your technology raisins.

This Technical Trade Presentation is sponsored in part by A-Tune Software, Inc.


IVC Rack Monitoring and Control—New Technology Advancements
3:00 PM - 3:20 PM/Room: 205
Speaker: Rick Deitrich
Moderator: Pat Guider

Since the introduction of rodent individually vented cage (IVC) systems in 1979, we continue to see innovations with respect to enrichment, plastic materials, modular design, and cage configurations, just to name a few. Key components of these IVC acks are the air supply and exhaust equipment that support these systems. This presentation will focus on the integration of rack monitoring and control systems. The new wireless sensor technologies provide 24-hour monitoring and data logging of air flow, pressures, air change rates, temperature, and humidity. Mobile apps provide remote access and status of the system, including text notifications and alarms. Secondly, we will discuss new advanced blower control systems that maintain proper airflow and cage air exchange rates.

This Technical Trade Presentation is sponsored in part by Thoren Caging Systems.


Documenting and Tracking Processes in Animal Isolators and Cleanrooms: How to Overcome Obstacles
3:20 PM - 3:40 PM/Room: 205
Speaker: Stephan Hammelbacher
Moderator: Pat Guider

Clinical research organizations help scientists to augment animal models in isolators. Researchers are increasingly working with gnotobiotic animals in isolators. The documentation of breeding processes, for example, in isolators supported by software is made more difficult by the fact that the hands in the isolators are tied by the glove ports and must be removed from the gloves for documentation. Likewise, it is difficult to perform intermediate recordings in isolators that can be reused outside the isolators. This presentation will show ways and means of performing process documentation in isolators without any active electronic components in the isolators, while leaving the hands in the gloves. Productivity progress is significant as a result of such measures and leads to significantly better data quality. The presentation is aimed at managers of large CROs using isolators, facility managers, researchers, supervisors, and animal technicians.

This Technical Trade Presentation is sponsored in part by Galilei Software GmbH.


Managing Your Breeding Core Like a Business
3:40 PM - 4:00 PM/Room: 205
Speaker: Laura Gee
Moderator: Kelly Rodriques

A breeding core provides reproductive services to the research community to reduce over-breeding, excessive per diem fees, and associated laboratory personnel costs. Breeding cores may struggle to find a balance between these services and the human, technical, and financial resources needed to perform them. Responsible operation of a breeding core requires the ability to think like a business manager and a scientist at the same time. With fundamental business strategies, the right communication, and tracking tools along with a best-practice mindset, breeding cores can optimize processes, provide measurable insights into core functions, and increase awareness and trust among the research community. Attendees will learn about the tools available to implement business strategies and improve overall breeding core function, communication, and return on services provided. The target audience may include, but is not limited to facility, veterinary, breeding core, colony managers, operations personnel/management, and IACUC members.

This Technical Trade Presentation is sponsored in part by SoftMouse.NET.


Controlling Your Controlled Substances—Using RFID to Monitor, Track, and Report on Controlled Drugs
4:00 PM - 4:20 PM/Room: 205
Speaker: Matthew Ruiter
Moderator: Pat Guider

With government regulation expanding, there is a growing need to accurately account for all controlled substances within laboratories. Recording drug inventory, user, and disposition data is a labor-intensive practice filled with errors and miscalculations. UID addresses these concerns by combining state of the art software with RFID technology to provide 100% accountability for all cabinet access, user, drug volume, disposition, use and full active inventory detail. This presentation will address how the daily challenges that are present with typical manual data entry systems are prevented by using RFID technology and enhanced software control processes to record and manage data automatically all while reducing costs and time.

This Technical Trade Presentation is sponsored in part by UID Identification Solutions (UID).

TRACK II – Optimizing Operations


Rodent Surgical Monitoring and Anesthetized Imaging
1:00 PM - 1:20 PM/Room: 203
Speaker: Brianna Sellers
Moderator: John Park

This presentation highlights the importance of rodent surgical monitoring and describes different rodent anesthesia options, specifically focusing on options available during rodent surgical model procedures and subsequent imaging follow-up. Topics discussed include inhalation versus injectable anesthesia, the physiological side effects of anesthesia, the necessity of supporting core body temperature, and performing monitoring during surgical procedures and rodent imaging. Further, this presentation details the increasing Institutional Animal Care and Use Committee (IACUC) requirements as well as the use of monitoring devices and anesthesia systems to adapt to these increased requirements.

This Technical Trade Presentation is sponsored in part by Scintica Instrumentation Inc.


Are Your Animals Dying During Surgery?
1:20 PM - 1:40 PM/Room: 203
Speaker: Dave FitzMiller
Moderator: John Park

While the reasons for losing animals during and after surgery are numerous, many are easily identified and preventable. Why is warming important? What vital signs should I monitor? How does postsurgical care impact survival rates? This presentation will answer these questions and provide animal surgeons and caregivers insights into the best methods for surgical and recovery care to ensure successful survival outcomes.

This Technical Trade Presentation is sponsored in part by Kent Scientific Corp.


Improving Pain Management and Medication Delivery Techniques for Better Laboratory Animal Welfare and Research Outcomes
1:40 PM - 2:00 PM/Room: 203
Speaker: Morgane Stum
Moderator: Jay Palmer

It is the ethical obligation of animal care professionals to reduce or eliminate pain and improve medication delivery in research animals while minimizing any interference to achieve research objectives. Managing pain through the application of analgesics and other therapeutics to reduce conditional distress are essential husbandry practices to support animal welfare. For laboratory animal veterinarians, lab technicians, and principal investigators, injections, oral suspensions, and medicated feed are the most common methods of medication delivery to manage compromised research animals experiencing varying degrees of distress. Unfortunately, the added stress from the handling and restraint to provide injections, the dosage inaccuracy of nonwater soluble suspensions, and low palatability of medicated feed for the compromised rodent contradicts best practices of animal health and welfare and can impede recovery. In addition, the traditional practice of injection or water bottle delivery can be labor-inefficient, requiring only qualified staff for administration of injection or extra time for staff to shake water bottles daily for resuspension of the therapeutic. ClearH2O's medication delivery gel products, MediGel®, MediDrop®, DietGel®, and LabGel® are nutritionally fortified dietary supplements containing various combinations of water, nutrients, minerals, and electrolytes to aid in consumption and recovery. These flavor-enhanced gels are pure and ready-to-use for mixing in the target medication. They are then placed into the recovering animal's cage in place of the water supply or as supplemental to its normal food source for easy administration of medication. The highly palatable gels promote consumption among recovering rodents, delivering medication in a convenient way without animal handling. Research results demonstrate that effective dosage can be achieved by oral consumption of medicated gels to achieve sustained blood levels of analgesics, antibiotics, and anthelmintics.

This Technical Trade Presentation is sponsored in part by ClearH2O.


Bedding: A Controllable Environmental Factor
2:00 PM - 2:20 PM/Room: 203
Speaker: René Ketelsen
Moderator: Bob Bentzinger

The potential impact that air, water, diet, caging systems, husbandry practices, and the animals themselves can have on the outcome of research data has been reviewed and guidelines established. Many husbandry standards have developed from accepted practices rather than from systematic data collection. Federal policies and accrediting agencies are increasingly requiring data to support performance-based standards or procedures. To date, there are no standards for laboratory animal bedding. According to the Guide, laboratory animal bedding is a controllable environmental factor. The influence it can have over experimental data is often overlooked. Minimizing environmental causes of physiological alterations in research animal populations has long been the focus of laboratory animal science. Laboratory animal science professionals, in consultation with the research staff, should select the most appropriate bedding which will not compromise the research data. This presentation will review the source, production, and the potential for microbial contaminants, phytoestrogens, mycotoxins, and endotoxins of the most commonly used bedding materials to confound research results.

This Technical Trade Presentation is sponsored in part by Shepherd Specialty Papers.


A Versatile Caging System to Collect Simultaneous Fluid and Electrical Samples from Freely Moving, Low-stress Rodents
2:20 PM - 2:40 PM/Room: 203
Speaker: Candace Rohde-Johnson
Moderator: Shelly Carballo

Awake animal studies are a preferred way to collect data, but typical caging systems are limited in the type and variety of samples that can be collected. When using a liquid swivel-based system, the study is constrained by the number of fluid lines available, and when using a commutator there are limits to both the number of lines and the quality of the signal. In addition, these two technologies typically aren’t compatible, meaning that you cannot easily have a wired connection and a fluid connection side by side in the same animal. This creates restrictions on study designs and often results in the use of additional animals to gather all of the necessary data. There is a commercially available caging system that circumvents these issues. This caging system reacts to the movement of the animal, turning only when needed to keep connected lines from tangling. This system makes it possible to connect a fluid line and electrical line side by side, or to connect multiple fluid lines (such as bile collection, bile salts infusion, dosing line, and blood collection line) in a single animal and can increase study throughput while reducing animal numbers. Additionally, rats and mice can be dosed and sampled from outside of the cage to reduce stress and minimize interaction with the subject. A final benefit of the system is that activity data can be easily collected to learn more about the movement of the animal while on study. During this session we’ll introduce the movement responsive caging system, review the types of data that can be collected, explore the effects of reduced stress on the animals, and share protocols which lead to a reduction in animal numbers. This session will be most beneficial for researchers performing awake animal studies that require dosing and sampling, but will have significant impact on those trying to combine protocols including e-phys, EEG, infusion, or repeated sampling. The data will also be relevant to any animal researchers interested in the effects of stress on animals during studies, particularly the stress that comes from human interaction.

This Technical Trade Presentation is sponsored in part by BASi (Bioanalytical Systems, Inc).


Designed to Be Different
2:40 PM - 3:00 PM/Room: 203
Speaker: Liz Kramer
Moderator: John Park

Ventilated rodent cages come in a variety of flavors, differing in air flow schemas, filter placement, blower control methods, and the convenience of disposables. What most ventilated caging has in common is the use of high velocity air passed over the bedding in order to rid the cage of contaminants. There is a new caging system that is designed to be different. It allows air to pass through the bedding rather than over it. The design affords the user a different experience including extended cage change, lower carbon footprint, labor efficiencies, and cleaner environment for the animal inhabitants. If the airflow can keep the bedding dry, ammonia generation will be low. The lower the ammonia, theoretically the longer the cage change interval. However, nobody changes cages based on performance data. Additionally, measuring ammonia is not a straightforward process. This talk will help to demystify some of the common challenges in measuring ammonia. The rationale for placement of the sensor, the different types of sensors, duration of the sensor exposure, and sample collection frequency will be discussed. Simple tricks for creating a sampling port will also be presented. The methods presented here were gathered during independent evaluations. The cost of research is rising, and translatability is being scrutinized. Can we afford to simply maintain the status quo or is it time to consider something different?

This Technical Trade Presentation is sponsored in part by Lenderking Caging Products.


Answering the Call of Wastewater Requirements in Laboratory Animal Care Cage Washing Products
3:00 PM - 3:20 PM/Room: 203
Speaker: Amy Ingraham
Moderator: Warren E Ball

The laboratory animal science facility benefits from the use of mechanical cage washers and chemical agents chosen to clean high numbers of cages in a short period of time. Facilities request cleaning products that are more efficient in aiding the removal of gross soils and very importantly, that remain stable in high-wash temperatures. These products are normally on the alkaline side of the pH spectrum, and some may require the use of a neutralizer prior to being released to a common drain. Additionally, these products may benefit from including phosphates, caustics, or sodium hypochlorite. In very hard water areas or when working with certain species, there is a definite need for acidic compounds to remove urine scale. Working within state and local effluent regulations and acknowledging our own advancements in cleaning technology, we will discuss a new direction to produce products that offer exceptional cleaning for rodent and rabbit soils, without the use of caustic ingredients, chlorine, or phosphates. This has produced a product for us that is performing in hard water conditions, while not requiring neutralization prior to discharge to effluent waste water. Meeting the expectations of regulatory requests, while providing a proficient cleaning product is sometimes like accomplishing “pure freaking magic."

This Technical Trade Presentation is sponsored in part by Pharmacal Research Laboratories.


Can Cleaners and Disinfectants Affect ATP Readings?
3:20 PM - 3:40 PM/Room: 203
Speaker: Nick Hidell
Moderator: Tim Hidell

Adenosine Triphosphate (ATP) monitoring systems, such as the AccuPoint™ Advanced system, are popular as an efficient, accurate, and economical method of surface cleaning validation. However, recently we have heard claims that certain types of cleaners/disinfectants may interfere with readings from ATP testing, causing inaccurate readings and rendering the testing unreliable. ATP is a protein that is present in all organic matter. Measuring its presence is a good indication of the organic soil load on a surface, and therefore the possibility that microbial life that may be hidden in that soil. This is particularly important because, without ATP, many facilities are using microbial plating—which is both expensive and slow—to determine if their cleaning efforts are sufficient. With ATP testing, cleaning practices can be tested instantly by measuring how much ATP is on a surface beforehand versus how much is there after cleaning. The question at hand is whether or not no-rinse cleaner/disinfectants left on a surface after cleaning will interfere with ATP measurements and cause inaccurate ATP readings. While surfaces should be cleaned and dried before testing, studies conducted by Neogen (manufacturer of the AccuPoint Advanced) show that the presence cleaner/disinfectant does not alter ATP testing results on properly cleaned surfaces. These tests were run against a variety of cleaner/disinfectants [b1] including quaternary ammonia, chlorine-dioxide and accelerated hydrogen peroxide. They found that none of the cleaners/disinfectants in the study affected the results of the ATP monitoring. A high ATP reading, even when cleaner/disinfectant is still present on the surface, indicates that the test site is dirty, i.e. the soil has not been adequately removed. If the site has been treated with a cleaner, a high ATP reading indicates either poor cleaning execution, or inadequate efficacy of the cleaner/disinfectant. It’s important for researchers and chemical manufacturers alike to take these claims seriously and consider the scientific literature when developing solutions for the constantly evolving microbiological challenges we all face.

This Technical Trade Presentation is sponsored in part by Quip Laboratories.


Improving Safety and Reducing Costs in Automated Vivarium Doors
3:40 PM - 4:00 PM/Room: 203
Speaker: William R "Bill" Britz
Moderator: Frank Herlihy

Access to many vivarium spaces, including storage alcoves and cage wash facilities, are controlled via automatic sliding doors. In many places, these doors are high-speed, guillotine-style, industrial roll-up doors. In other areas, horizontal sliding doors are utilized which require significant wall space. This presentation will examine the use of these doors with regard to personnel safety, construction cost, and long-term maintenance and operation costs. Safer and more cost-effective options will be considered. Architects, planners, and those responsible for vivarium design will benefit from this presentation.

This Technical Trade Presentation is sponsored in part by Britz & Company.


The Science and Safety behind the White Suits
4:00 PM - 4:20 PM/Room: 203
Speaker/Moderator: Alex Bradley

Providing safer work environments through education, awareness, and training is a critical process. The broad landscape of industry standards, complex regulations, chemical cleaning, or biological safety requirements can be challenging. A wide variety of options ranging from coveralls, sleeves, and shoe covers make the selection of personal protective equipment (PPE) ensembles difficult. Industry advancements ranging from communication technologies, analytical capabilities, and material science allow for continuous improvement in the selection of PPE relative to workplace health and safety. This presentation will address the connection between the science of PPE and the overall application to industry PPE requirements. We will compare selection options driven by the standard operating procedures in a controlled (or sterile) lab environment versus those needed to address pandemic outbreaks. Some relevant industry hazards influencing the balance of protective apparel design attributes such as protection, durability, and comfort while maintaining the need for compliance will be surveyed. The audience will learn about interactive software tools for desktop or mobile devices that provide data to help them make their informed decisions about PPE. Attendees will see the benefit of having selector resources at their disposal. A demonstration will focus on showcasing different job scenarios that require various levels of PPE applications. Participants will be able to identify appropriate industry standards for selecting PPE as well as recognize the benefits and limitations associated with the intrinsic methodology. In addition, audience members will learn to identify and differentiate protective apparel design attributes by understanding the fundamental aspects of material selection as it relates to the hazard assessment.

This Technical Trade Presentation is sponsored in part by DuPont Protective Apparel.