TUESDAY MORNING

WORKSHOPS


W-02 CMAR/Animal Resource Exam Prep Class continued (8-hour workshop continued from Monday 8:00 AM)

8:00 AM - 12:00 PM/Room: 346
Leader: Diana P Baumann
Faculty: Diana P Baumann, Camellia M Symonowicz
Facilitator: TBD

See Monday 8:00 AM for pricing and description.

W-05 Essentials of IACUC Administration continued (8-hour workshop continued from Monday 1:00 PM)
8:00 AM - 12:00 PM/Room: 348
Leaders/Faculty: Elaine K Kim, Stacy L Pritt, Trina Smith
Facilitator: Ashley Savannah

See Monday 1:00 PM for pricing and description.

This Workshop is sponsored in part by Public Responsibility in Medicine and Research (PRIM&R).

W-10 Leading the Self and Others with Emotional Intelligence
8:00 AM - 12:00 PM/Room: 349
Leader/Faculty: Jamie Mueller
Facilitator: Temeri Wilder-Kofie
Workshop Fee: $140 Workshop Limit: 50

The first person you lead is yourself. We know that meaningful and sustainable leadership works through emotions. This workshop will increase participants awareness and understanding of emotional intelligence (based on the Goleman model), explore the leadership competencies of emotional intelligence, and provide insight on how leaders handle themselves and their relationships with EQ. Specifically, participants will develop their awareness around emotional intelligence skills, specifically around self-awareness, self-management, social awareness, and relationship management and define their own leadership strengths and style and understand alignment between their values and leadership behavior. The workshop is targeted to leaders, directors, and managers who are in an existing leadership role or will be in the future and wish to better understand the key competencies necessary to lead in today's fast-paced and ever-changing environment.

W-08 Teaching Monkeys to Cooperate with Restraint: Using Positive Reinforcement Training and Temperament Testing Methods (8-hour workshop continued from Monday 1:00 PM)
8:00 AM - 12:00 PM/Room: 345
Leader: Jaine E Perlman
Faculty: Mollie A Bloomsmith, Kristine Coleman, Jennifer L McMillan
Facilitator: Mark J Prescott

See Monday 1:00 PM for pricing and description.

This Workshop is sponsored in part by NC3Rs, Lomir Biomedical Inc, Carter 2 Systems and HYBEX Innovations Inc.

SEMINARS


Comparative Approaches to Monitoring Rodent Colonies for Infectious Agents
8:00 AM - 10:15 AM/Room: Ballroom I
Leader/Moderator: Robert S Livingston
Facilitator: Sharon Byras

Monitoring rodent colonies for infectious agents is continuing to evolve along with the increased use of individually ventilated caging (IVC) systems, the availability of highly sensitive PCR testing methods, and the desire to reduce the use of sentinels exposed to soiled bedding. In this seminar, participants will be shown data from recent real-life and experimental studies comparing the diagnostic sensitivity of detecting viral, bacterial, and parasitic infections of mouse or rat colonies by testing IVC plenum debris, filters exposed to composite soiled bedding, colony animals, and soiled bedding sentinels. Pros and cons of these different approaches will be discussed, and how to incorporate some novel monitoring methods into your own health surveillance programs. This seminar will be of interest to individuals managing or participating in monitoring the health of mouse and rat colonies.

Speakers/Topics:

8:00 Matthew H Myles Welcome and Introduction
8:10 Patricia Foley PCR Testing of Filter Paper from IVC Cage Lids for Microbial Monitoring of Mouse Colonies
8:35 Cynthia L Besch-Williford Detection of Mouse Pathogens in Exhaust Debris Samples from Individually Ventilated Caging Systems
9:00 Aurore Dodelet-Devillers External Validation of Exhaust Air Dust Testing by Comparison with Traditional Soiled Bedding Sentinels
9:25 Robert S Livingston Novel Approaches to Cage Level Monitoring

Current Research on Mouse Home Cage Aggression

8:00 AM - 10:15 AM/Room: Ballroom II
Leader/Moderator: Brianna N Gaskill
Facilitator: TBN

Aggression is the second most common reason for veterinary clinical care in laboratory mice and can lead to severe injury and death. Aggression accounts for 15% of clinical cases, meaning that the potential for injury and suffering affects millions of mice every year. High levels of aggression can induce immune suppression, resulting in poor welfare and unwanted variation in scientific models. Along with replacement of dead or euthanized animals, this leads to increased overall animal use. This session will share the results of a series of studies performed to identify environmental triggers, evaluate best practices, and further understand mouse behavior. Participants in this session will learn about the biology of aggression in mice, the characterization of aggression in various strains of mice, and the effectiveness of current best practices. This information will be useful for research staff, animal care staff, veterinarians and vivarium managers that work with mice.

Speakers/Topics:

8:00 Brianna N GaskillWelcome and Introduction
8:15 Brianna N GaskillEvaluation of Housing Suggestions in a Simulated Tox Environment
8:45 Joseph Garner and Jacob TheilAn Epidemiological Approach to Mouse Aggression
9:15 Jamie Ahloy DallaireHow Should We Split Cages of Mice with Severe Aggression?
9:45 Amanda BarabasOlfaction and Aggression in the Laboratory

Microbiome Research Developments Using Mouse Models

8:00 AM - 10:15 AM/Room: Ballroom III
Leader/Moderator: Betty R Theriault
Facilitator: John J Hasenau

Emerging research investigating the role of the host microbiome in health and disease has provided revolutionary insight into the complexity of microbiome influence on host immunologic, metabolic, and physiologic pathways. However, microbiome research remains in its infancy. Interrogation of the complex intersection of host microbiome and system response has led to the revalidation of existing mouse models of human disease and to the development of novel animal models. We will explore both the science and the technology of this emerging field. The complexity of traditional specific pathogen-free mouse models and the influence of the microbiome on disease modeling and reproducibility will be explained. The progression and development of a mouse model of food allergy and the associated mucosal immunology will be reviewed as an example of validation of existing mouse models. Description of the value and limitations of refinements in the model as well as the success in the translatability of a human fecal microbial transplant model in ex-germ free mice will be mentioned. Further, challenges and opportunities faced by the laboratory animal community in support of microbiome research will be explored. The challenges of existing facility design and equipment require consideration of associated biocontainment and biosecurity concerns when using (human) microbiota. The integration of flexible film and semi-rigid isolator housing with biocontainment and bio-exclusion ventilated rack technologies for the demand of high throughput studies will be discussed. The session will close with a presentation of technical experiences in managing a gnotobiotic facility with the current technologies for germ-free and gnotobiotic research. A discussion will close out the seminar. This seminar session is insightful for all individuals at all levels in laboratory animal care programs. This session is a must for anyone interested in microbiota and rodent modeling, including recent advances in humanizing rodent microbiota.

Speakers/Topics:

8:00 Betty R Theriault Welcome and Introductions
8:05 Betty R Theriault Gnotobiology, History, and Evolving Omics
8:15 Craig L FranklinComplex Gnotobiology; What Are Our Current Mouse Models Telling Us
8:40 Cathryn Nagler A Researcher's Use of Mouse Models for Human Microbiome Modeling
9:25 Betty R TheriaultProgramatic and Biosafety Concerns in Development of Mouse Models of Human Microbiomes
9:45 Jessica K LangTechnical Components of Managing a Gnotobiology Facility
10:05 John J HasenauDiscussion

Treating Wounds and Using Antibiotics Appropriately: Practical Tips and Case Examples

8:00 AM - 10:15 AM/Room: Ballroom IV
Leader: Jeffrey D Fortman
Moderator: Joseph Sciurba
Facilitator: Tracy E Latalladi

This seminar will include three subtopics. The first will provide a brief history of wound care and antibiotic discovery. The second will review practical wound management techniques, including topics such as how to identify the different stages of wound healing, how to assess and care for acute wounds, and how to deal with nonhealing wounds. The final lecture will cover how to choose and use antibiotics appropriately. It will also highlight different classes of antibiotics, types of bacteria associated with common infections, and the related concepts of antimicrobial resistance and antibiotic stewardship. The target audience includes animal health technicians, veterinary technicians, and junior level veterinarians. Participants will learn a history of where and how antibiotics originated, the development of wound management through time, practical management techniques for common wounds, and when and how to use antibiotics properly. The seminar will end with interactive case examples that allow participants to apply newly acquired knowledge to real-life scenarios.

Speakers/Topics:

8:00 Jeffrey FortmanWelcome and Introductions
8:10 Jeffrey FortmanWhen Life Gives You Mold, Make Penicillin: A Short History of Antibiotic Discovery and Unusual Approaches to Wound Care
8:40 Alexandria A SmithTime Heals All; Strategies and Techniques to Manage Commonly Encountered Wounds
9:05 Kathleen CodaBefore You Grab that Antibiotic, Listen to This!

PLATFORM SESSIONS

8:00 AM-10:45 AM

Platform Session abstracts will be available on www.aalas.org in July. They will also be included in both the mobile app and the National Meeting Final Program.

SPECIAL TOPIC LECTURES


America's Wild Horses: Living Legends or Faded Legacy?

11:00 AM - 12:00 PM/Room: Ballroom III
Speaker: Brian Smith
Moderator: Allison M Williams
Facilitator: Kimberly Y Jen

Wild horses and burros are defined as unbranded, unclaimed, free-roaming animals found on public lands in the U.S. Most are descendants of animals released or escaped from Spanish explorers, ranchers, miners, the U.S. Cavalry and Native Americans. In the 1940-50s, mustangers caught wild horses using planes and trucks; some sold to ranchers or rodeos. However, most were shipped to processing plants and canned as pet or fur-farm food. Velma B. Johnston (Wild Horse Annie), campaigned against the brutal and inhumane roundup, sell, and slaughter of wild horses which led to a series of legislation. The first, in 1959, prohibited the use of motorized vehicles to hunt wild horses and burros on public lands. The Wild and Free-Roaming Horses and Burros Act of 1971 was passed, providing management, protection, and control of wild horses and burros on public lands. Congress declared, in part, “wild free-roaming horses and burro are living symbols of the historic and pioneer spirit of the West; that they contribute to the diversity of life forms within the Nation and enrich the lives of the American people.” The management of these animals has always been a political issue. These animals ultimately become part of roundups, called “gathers” conducted by the Bureau of Land Management (BLM). These gathers are an effort to keep the herds to manageable levels. The speaker, who retired from the US Army in 2003 and is currently a Las Vegas police officer, founded a nonprofit organization called Funny Farms Mustangs. This organization works closely with the Mustang Heritage Foundation (MHF) to benefit horses/burros. His organization’s mission is to train these wild horses and burros using a unique technique, known as gentling, to prepare them for adoption. Aside from trail riding and competition, these horses are also used in the workforce to support the Border Patrol and the Mounted Police units throughout the country. The target audience includes anyone supporting the use, training, education, or research of equine with an emphasis on feral horses and burros that live in the wild of the U.S.

This Special Topic Lecture is sponsored in part by American Society of Laboratory Animal Practitioners/American College of Lab Animal Medicine Program Committee (ASLAP/ACLAM).

Charles River Ethics and Animal Welfare Lecture: Assessing Laboratory Animal Wellbeing: The Study of Animal Affect
11:00 AM - 12:00 PM/Room: Ballroom I
Speaker: Michael T Mendl
Moderator: Patricia V Turner
Facilitator: TBN

The wellbeing or welfare of laboratory animals is a concern for all who work with them, as well as for wider society. For many people, this concern reflects an assumption that animals are capable of suffering; that is experiencing negative emotional or affective states—the animal equivalent of feelings that we label with words like "fear," "anxiety," "sadness," and "depression." In contrast, although we readily accept that plants can malfunction and be diseased, we rarely speak about their welfare because most of us do not believe that they are able to suffer. If affective states are the key determinant of animal wellbeing, then we need to be able to assess these states in order to monitor laboratory animal welfare and detect when welfare problems arise and how effectively they are ameliorated by refinements to housing and management. But this is a challenging enterprise. Although we can use language to communicate our own emotional feelings to each other, they remain essentially private subjective experiences, so how can we hope to assess the emotions of other nonlinguistic species? In this talk, the following topics will be introduced: a scientific approach to the assessment of animal affect and an outline of the assumptions that need to be made; an operational definition of animal emotion that provides a grounding for experimental studies; and the theoretical and empirical underpinnings of an approach that we have developed and the work on laboratory rodents that has been done using this approach. The talk will end by briefly considering whether the affective states that we may infer in other species are consciously experienced. Although most methods for assessing animal affect sidestep this question, new developments in the cognitive and neurosciences may bring us closer to an answer. The targeted audience includes all AALAS attendees.

This Special Topic Lecture is sponsored in part by Charles River.

Developing a Meaningful Health Monitoring Program for the Aquatics Facility
11:00 AM - 12:00 PM/Room: Ballroom IV
Speaker: Jason Collins
Moderator: TBN
Facilitator: TBN

An aquatics facility health monitoring program should utilize disease surveillance and screening of discrete populations based on statistical sampling models to catch potential gaps in biosecurity protocols, as well as provide evidence as the foundation for biosecurity decisions. This lecture will address the big questions to consider when developing a health monitoring program: how many fish to sample, what do I check, where to sample from, what is my biosecure unit, and how frequently should I test?

Wallace P Rowe Lecture
11:00 AM - 12:00 PM/Room: Ballroom II
Speaker: TBN
Moderator: Lon Kendall
Facilitator: TBN

Speaker and description will be available after the Award Selection Committee selects the Bhatt Award Recipient. This session information will be available in the mobile app and in the Final Program.

This Special Topic Lecture is sponsored in part by Committee for Laboratory Animal Training and Research (CLATR).

TUESDAY AFTERNOON

PANEL DISCUSSIONS


Efforts to Increase Research Transparency in the U.S.

12:30 PM - 2:00 PM/Room: 337
Leader/Moderator: Paula A Clifford
Facilitator: Carrie Gibson
Panelist: Cindy A Buckmaster, Chris Barncard, Lisa Newbern, Jim Newman

Research involving animals contributes to scientific and medical progress benefitting humans and animals alike. Because of these significant impacts to public health, many U.S. institutions, scientists, and organizations are already committed to increased transparency about their research and are interacting with the public regularly to help expand understanding of the benefits of animal research. However, these efforts are not as widespread as needed. According to recent public opinion surveys, approximately half or fewer Americans support health research involving animals. In addition, the tactics used by activist groups are evolving and recent lobbying efforts are starting to result in restrictions on research. Several initiatives are currently taking place in the U.S. to increase transparency around animal studies. A grassroots campaign is underway to build both individual and institutional support for a U.S. openness agreement. If successful, such an agreement would demonstrate a shared understanding for the need to increase communications and transparency about the role of animals in research. Participants in an openness agreement would also pledge to take certain steps to help increase public knowledge and understanding. The ongoing efforts in the U.S. are based on and influenced by similar openness initiatives in the UK and other European countries. Session participants will learn why increased transparency is essential. They will find out which U.S. institutions can serve as models for proactive engagement with the public. Audience members will engage in discussion with the panelists to learn how various openness models work and how they can be applied to their own institutions as well as how they can to join the emerging U.S. effort, either as individuals or as entire institutions.

This Panel Discussion is sponsored in part by Americans for Medical Progress and National Primate Research Center.

Is Biological Materials Testing Included in Your Animal Resources Biosecurity Program?
12:30 PM - 2:00 PM/Room: 339
Leader/Moderator: Cindy L Besch-Williford
Facilitator: Sharon Byras
Panelist: Beth A Bauer, Cindy L Besch-Williford, Melinda Hollingshead, Lois A Zitzow

Immunocompromised rodent models engrafted with transplantable cells and tissues are valuable preclinical models to study human cancer, degenerative, and infectious diseases. Model development involves the use of various biological materials derived from man or animals, such as patient-derived xenografts, human blood cells, and cell lines for tumor formation. These important research reagents can complicate and nullify in vivo studies if contaminated with infectious agents or with cells from another species or cell line. The possible negative outcomes of using contaminated biological materials include infectious disease outbreaks if the biological material contains rodent pathogens, risk of exposure of laboratory and vivarium personnel to human infectious agents if the biological material is of human origin, and the loss of animals and resources if the biological material was misidentified or contaminated with other cells. This panel discussion will overview the contribution of contaminated biological materials to the reproducibility crisis in preclinical research and provide real-life examples of biological material contamination and the screening methods that can be instituted as part of a comprehensive biosecurity program. The targeted audience is laboratory animal veterinarians, facility managers, and animal welfare policy and compliance personnel.

Preparing and Supporting Veterinary Technicians for Leadership and Regulatory Roles: Establishing High Industry Standards
12:30 PM - 2:00 PM/Room: 341
Leader: Chrystal L Montgomery
Moderator: Summer M Boyd
Facilitator: Vicki Elam
Panelist: Chrystal L Montgomery, Ann L Murray, Phillip N Sullivan, Mark T Sharpless

Veterinary technicians are often expected to perform a variety of critical roles, ranging from providing nursing care and assisting with staff training and development to participating in regulatory oversight. An experienced veterinary technician is an ideal candidate for many leadership roles within an animal care and use program. Knowledge, skills, and experience will enable well-qualified technicians to create health monitoring programs, assist with sophisticated and complex surgeries and anesthesia, provide guidance and mentorship to new or less experienced technicians, help to establish professional career tracks, assist in architectural designs, and to successfully navigate regulatory and compliance requirements. These are just a few examples of the many key roles which veterinary technicians fill. This panel discussion will explore pathways and examine resources specific to veterinary technicians to guide them to a leadership or regulatory position. Personal insight and suggestions on how to position themselves for these types of roles will come from industry professionals working in academia and industry. These individuals have experience in various roles including, IACUC, training, facility management, and GLP environments. The discussion will also cover educational requirements, as well as licensure and certification which will aid in finding a career in management or in the regulatory capacity. The target audience includes veterinary technicians, animal care technicians, research technicians, vivarium managers, and administrative staff.

This Panel Discussion is sponsored in part by Society for Laboratory Animal Veterinary Technicians/Academy of Laboratory Animal Veterinary Technicians (SLAVT/ALAVTN).

Vivarium Ergonomics: Practical Improvement Ideas that Work
12:30 PM - 2:00 PM/Room: 343
Leader: Melissa A Hostrander
Moderator: Pamela A Straeter
Facilitator: Joanne C Drew
Panelist: Denise A DiFrancesco, Melissa A Hostrander, Terry Snyder

Employers are responsible for providing a safe and healthy workplace for their workers. Whether the job involves working at a desk or moving large equipment in the lab, ergonomics plays a key factor in safer day-to-day activities. Ergonomics is the science of fitting the job to the worker and make the job easier to perform. Good ergonomic design and practices reduce fatigue, discomfort, and injury, including musculoskeletal injuries that can lead to work disability. Productivity and work quality are often improved, as the jobs get easier. When ergonomic aspects are ignored, significant negative consequences can occur. The goal of this panel is to help the participant understand common musculoskeletal risk factors and practical ideas to address these problems regardless of the size, budget, or complexity of their vivarium. Using examples of specific job task, panel speakers will review the musculoskeletal risk factors and show practical ideas for improvements. Strategies to overcome obstacles to making these changes will also be discussed. Time will be available for attendees to share their ergonomic success stories and challenges.

Seminars


Easing the Transition for Animals Entering the Vivarium and Reducing Stress During Transportation
2:45 PM - 5:00 PM/Room: Ballroom I
Leader: Nicole Navratil
Moderator: Derek Brocksmith, Michelle L Salerno
Facilitator: Jeffrey DiMayo

Transport and transition from the breeding facility to the laboratory can be a source of stress for laboratory animals, particularly for disease models and juvenile animals. It is valuable for laboratory staff to understand the differences between the laboratory environment and the breeding environment that the animals originate from to help develop effective acclimation programs. This seminar will bring together veterinarians and animal care experts from several major breeding facilities. Presentations will address recurring concerns related to transportation stress, maintaining animal welfare during transportation and post-arrival acclimation, housing, and husbandry. The goal of the session is to discuss ways to identify and reduce stress associated with transportation and acclimation and to improve the overall well-being of the animals. This session will cover minipigs, dogs, rabbits and rodents. The target audience includes those involved with the procurement, transportation, and post-arrival acclimation and care of laboratory animals. This includes technicians, behavioral specialists, facility managers, veterinary staff, transportation coordinators, drivers, and procurement specialists.

Speakers/Topics:

2:45 Nicole NavratilWelcome and Introduction
3:00 Derek BrocksmithSpecial Considerations for Shipping and Acclimation of Diabetic and Atherosclerotic Minipigs
3:20 Michelle SalernoShipping Concerns and Acclimation of Juvenile Minipigs and Dogs
3:40 Rick VanDomelenPreparing for the Transition and Mitigating Shipping Stress in Laboratory Canines
4:00 Paul KnepleyShipping and Acclimation of Rabbits
4:20 Guy B MulderShipping and Post-arrival Considerations for Rodents
4:40 Krishnan KolappaswamyApplication of Lean Six Sigma Principles in Improving Animal Welfare During Transportation

This Seminar is sponsored in part by The North America Laboratory Animal Breeders Association (LABA).

Microbiota in Rodent Models: Reproducibility, Translation, and Discovery
2:45 PM - 5:00 PM/Room: Ballroom II
Leader: Jacob E Moskowitz
Moderator: Cindy L Besch-Williford
Facilitator: Nick Harrison

The gut microbiota (GM) is the complex community of commensal, symbiotic microorganisms that occupy the intestinal tracts of animal species. The GM has emerged as a critical homeostatic regulator of host physiology with implications in a surprisingly diverse range of physiological processes. Given the variable environmental exposure and genetics of human populations, rodent models emerged as effective systems to manipulate these complex ecosystems to elucidate microbiological contributions to health and disease. Here we consider how our growing understanding of the GM can address key issues in laboratory animal research, including reproducibility, translatability, and discovery. It is evident that a number of different environmental and husbandry-related factors affect the microbiota. Of importance to the biomedical research community is the growing wealth of data showing that differences in complex GM are associated with model phenotype variability, which may significantly impact model reproducibility and translation to human disease. This seminar will address a range of factors known to influence the GM with the aim of fostering increased awareness of these variables in both academic and industry settings. The emerging microbiota field has provided several tools for manipulating the GM in animal models, ranging from classic gnotobiology strategies such as reconstituting axenic mice with defined flora or human microbiota to exploiting existing GM differences in contemporary rodent colonies through procedures such as complex microbiota targeted rederivation. We will discuss the use of these techniques to enhance reproducibility and translatability and demonstrate the integration of GM data to further facilitate discovery in animal research, covering specific examples of both intestinal and neurodevelopmental diseases. This seminar is suited for a broad range of audience members, including veterinarians and animal care staff aiming to facilitate reproducible and translatable animal research through increased understanding of the microbiota, and research scientists with interests in a broad range of pathological processes.

Speakers/Topics:

2:45 Craig L FranklinWelcome and Introduction
2:50 Craig L FranklinAn Introduction to Microbiota: Considerations in Contemporary Rodent Research Colonies
3:15 Irka RedelspergerThe Laboratory Mouse Microbiome- A Commercial Vendor's Perspective
3:40 Aaron EricssonLost in Translation: Modeling Human Disease Via the Gut Microbiota
4:05 Marcia L HartAssessing the Influence of Gut Microbiota on Rodent Model Phenotype
4:30 Jacob E MoskowitzIntegrating the Gut Microbiota: A System's Approach to Colorectal Cancer

The Use of Humanized Animals in Biomedical Research
2:45 PM - 5:00 PM/Room: Ballroom III
Leader: Jason S Villano
Moderator: Patrick E Sharp

Facilitator: TBD

Research using laboratory animals has been revolutionized by the development of humanized animal models, which are immunodeficient animals engrafted with human cells, tissues, or organs. These animal models provide the research community a promising opportunity to mimic a wide variety of disease conditions in humans, from infectious disease to oncology research. A vast majority of these models are humanized mice like those injected with human CD34+ hematopoietic stem cells and patient-derived xenografts. With the increasing use of these animals in biomedical research, the laboratory animal science community needs to understand these models and their care and use. This seminar includes talks on ethical and safety considerations in creating and using humanized animal models and common small and large animal models and the unique challenges for veterinary and husbandry care of these animals. We will conclude the seminar with a talk on future directions involving this technology. This seminar is appropriate for all attendees, including those in management, veterinarians, IACUC members, compliance and biosafety officers, researchers, and animal care staff.

Speakers/Topics:

2:45 Patrick E Sharp Welcome and Introduction
2:55 Patrick Lester Humanized Small Animal Models
3:20 Stephen Felt Humanized Large Animal Models
3:45 Allison R Rogala Ethical and Philosophical Considerations
4:10 Jason Villano Safety Considerations in the Use of Humanized Animals
4:35 Michelle Creamer-Hente Future Directions: Humanized Animals

Updates on Rodent Anesthesia and Postoperative Analgesia
2:45 PM - 5:00 PM/Room: Ballroom IV
Leader/Moderator: James O Marx
Facilitator: TBN

Anesthesia and postoperative analgesia are very common procedures in rodents in biomedical research and both have profound impact on both the quality of the experimental data collected and the welfare of the animals. In the past few years, over 50 publications have come out in JAALAS alone with new information to improve both anesthesia and postoperative analgesia in rodents. Based on this, we believe it is time to present some of the new updates on rodent anesthesia and postoperative analgesia. There are many important aspects of these topics. The initial anesthetic protocol needs to consider the depth of anesthesia required for the procedure, the duration of the procedure, and the potential impact of the anesthetics on dependent variables. Many recent publications have presented new anesthetic drugs and protocols to meet these needs in rodents. Frequently, some procedures require more time of anesthesia than is provided by the initial dose, requiring the redosing of anesthetics. Lastly, postoperative care, including both analgesia and monitoring, is critical to the welfare of the animals. This seminar will present an update on the newest recommendations for these topics. The intended audience is scientists, veterinarians, veterinary technicians, and IACUC members.

Speakers/Topics:

2:45 James O Marx Welcome and Introduction
2:50 James O Marx The Newest in Anesthetic Protocols in Rodents
3:25 Cholawat Pacharinsak After the Initial Dose: Redosing Injectable Anesthetics
4:10 Jennifer C Smith After the Surgery: Postoperative Analgesics and Monitoring
4:40 James O MarxGroup Discussion