Wednesday, October 16
MORNING

WORKSHOPS


W-10 CMAR Preparatory Class for the Animal Resources (AR) Exam
(8-hour workshop continued from Tuesday 1:00 PM)
8:00 AM - 12:00 PM/Room: 302
Leader/Faculty: Diana P Baumann
Facilitator: TBN
See Tuesday 1:00 PM for pricing and description.

W-12 Introduction to Flexible GI Endoscopy in Laboratory Animals

8:00 AM - 12:00 PM/Room: 607
Leaders: Kelly A Rice, Marvin L "Tom" Thomas
Faculty: Kelly A Rice, Marvin L "Tom" Thomas, Patrick McElwee, Matthew W Breed, Jessica M Izzi
Facilitator: Holly M Habbershon
Workshop Fee: $150 Workshop Limit: 20

This workshop is targeted towards laboratory animal veterinarians and technicians with a large-animal focus. Flexible GI endoscopy represents an important diagnostic and research support tool for the practicing laboratory veterinarian. It is a specialized skill, but provides a virtually pain-free, minimally invasive approach to evaluating GI health and obtaining tissue samples for definitive diagnosis. Laboratory veterinarians are increasingly called upon to assist with experimental endoscopic biopsies for large-animal models. Further, non-specific gastrointestinal signs are not an uncommon presentation for large laboratory animals with spontaneous disease. This introductory workshop aims to provide a foundation for laboratory veterinarians with a focus on endoscopic equipment, diagnosis, and integration of flexible endoscopy in the laboratory setting. Techniques for nasopharyngoscopy, esophagoscopy, gastroscopy, enteroscopy, colonoscopy, and tissue biopsy will be discussed. This half-day workshop will consist of lecture- and video-based learning and discussion followed by a hands-on laboratory to familiarize participants with the endoscopy equipment and allow for technical instruction and practice using nonanimal teaching models.

W-13 LAS Pro Article Writing Boot Camp

8:00 AM - 12:00 PM/Room: 304
Leaders: John Farrar, Liz Rozanski
Faculty: Robert T Dauchy, Penny L Devlin, Jamie Naden, Elizabeth A Nunamaker, Robin Tucker, Andrew J Burich, Karuna Patil
Facilitator: TBD
Workshop Fee: FREE Workshop Limit: 50

Laboratory Animal Science Professional, the flagship AALAS publication, features articles highlighting the latest developments and strategies in management, professional development, occupational health and safety, as well as technician tips and feature stories on the diverse professionals who work in our field. Do you want to be a part of your association’s magazine? Bring your concepts or an article outline and we will help you get started down the road to publication! The magazine’s Editorial Advisory Board will be on hand to offer encouragement and expert advice. The targeted audience for this workshop is any AALAS member looking to publish, particularly those who have not published previously. Participants are encouraged to bring their own laptops to the session.

W-14 Legislative Advocacy: Watering the Grassroots

8:00 AM - 12:00 PM/Room: 303
Leader: Anita T Richert
Faculty: Logan K France, Kari L Chesney, Rocco Praglowski
Facilitator: Paula A Clifford
Workshop Fee: $150 Workshop Limit: 50

Today, more than ever before, the biomedical community faces innumerable challenges when it comes to legislative affairs. The ease with which pseudoscience and misinformation is shared via online platforms has made the job of biomedical researchers exponentially more difficult. Legislators are looking for input on issues facing the science community and those involved in animal research have a unique and important voice to share. If the biomedical research community does not take the opportunity to stand up and speak about the importance of this work, the ability to aid in public health and safety through medical advancements will be severely hindered. The goal of this workshop is to teach attendees how to stay informed, who to contact, and what to say. Attendees will leave feeling empowered with a clear understanding of the importance of their voice. The workshop will allow attendees to implement new skills and practice communication about animal research. Conduct during legislative meetings and discussions with elected officials will also be covered. Attendees will gain an understanding of how to serve as a resource and science expert for local and federal government officials to ensure they are fully informed when making decisions regarding laws and regulations. The importance of educating friends and family about animal research will also be highlighted. Participants will learn the how, when and where of legislative advocacy from writing a letter to your legislator to making a trip to Washington D. C. Participants will hear from multiple young professionals that actively participate in legislative advocacy in many different capacities. Anyone interested in learning more about being an advocate from the biomedical community.

This Workshop is sponsored in part by National Association for Biomedical Research (NABR) and Americans for Medical Progress (AMP).


SEMINARS


A Comprehensive Approach to Maximizing Facility Biosecurity and Animal Welfare across Geographically Diverse Locations

8:00 AM - 10:15 AM/Room: Mile High Ballroom 1A
Leader: Guy B Mulder
Moderator: Peggy J Danneman
Facilitator: Allison M Williams

The speakers will present a comprehensive performance-oriented approach that successfully harmonized husbandry, facilities, and engineering operations across 17 sites in 8 countries to achieve consistently high levels of animal welfare and facility biosecurity. Utilizing a team approach that included veterinary, engineering, facilities, and production personnel, performance standards were defined for all facets of operations that impact biosecurity and animal welfare of commercially produced research animals. Performance standards were developed for 26 distinct topics, ranging from aseptic cage and surgical processes, colony management, animal drinking water, pest control, critical spare parts, and redundancy and preventative maintenance for critical equipment such as HVAC systems and bulk autoclaves. We will provide an overview of the global biosecurity imperative program and provide examples of how performance standards were developed, as well as how standards are implemented at the site level. We believe a similar approach connecting engineering design to vivarium and facility operations may be beneficial to both small and large institutions. The target audience includes those involved with the oversight, implementation and management of animal facilities including vivarium managers, veterinarians, and facilities personnel.

Speakers/Topics:

8:00Peggy J DannemanWelcome and Introductions
8:05Guy B MulderOverview of a Biosecurity Imperative Program and Development and Harmonization of Critical Performance Standards
8:45Ivan KousidisEngineering-based Biosecurity Imperatives: Why Issuing an SOP Isn't Enough
9:25Peter Trocco Practical Aspects of Maintaining Bio-secure Animal Facilities

This Seminar is sponsored in part by ACLAM/ASLAP Joint Program Committee.

Murine Chapparvovirus aka Mouse Kidney Parvovirus: A Novel Virus Identified Using Metagenomics
8:00 AM - 10:15 AM/Room: Mile High Ballroom 2A
Leader/Moderator: Neil S Lipman
Facilitator: Sean Kelly

Most of the infective agents we recognize today, whether they are primary pathogens, opportunists, or commensals, were identified as they were cultivatable, observable, and/or shared features with agents identified using the former methods. The advent of metagenomics has changed this paradigm. Metagenomics, a broad variety of research techniques using molecular biological methods to identify communities of organisms at the genomic level, has become an increasingly important tool in the identification of novel microbial agents, both those associated with changes in the host, as well as those of unknown or undefined significance. Metagenomics is already having a significant impact in laboratory animal science and this impact will certainly increase. The speakers will review metagenomic methods and how they can and have been employed to answer important questions. Novel information will be presented on several rodent viruses recently identified using metagenomics, notably murine astrovirus, mouse kidney parvovirus, and rat polyomavirus, as well as a large number of previously unrecognized viruses found in wild Mus musculus. The seminar will conclude with a discussion in which the presenters will deliberate as to what criteria the laboratory animal science community should consider using to determine whether a specific agent is of sufficient concern, that its presence should be identified, and when it should be excluded. This seminar will be of considerable interest to many meeting attendees as novel information will be presented on three emerging laboratory rodent viruses as well as other viruses that can potentially infect the laboratory mouse.

Speakers/Topics:

8:00Neil LipmanWelcome and Introductions
8:05Sebastien MonetteThe Discovery of Murine Chapparvovirus (MuCPV) aka MKPV
8:25Ben RoedigerEvolution, Dissemination, Tropism, and Molecular Features of Mouse Kidney Parvovirus (MKPV) and Related Parvoviruses
8:45Mandy L KainExploring the Pathogenesis of and Strain Susceptibility to MuCPV
9:10Chuanwu WangMolecular Diagnosis of MuCPV
9:25Rajeev K DhawanSerologic Detection of MuCPV
9:35Robert S LivingstonMuCPV Detection in Comprehensive Health Monitoring Programs
9:55Kenneth S HendersonCriteria to be Used for Selection of Agents for Testing and Exclusion


Who's Driving the 3Rs/Welfare Science and Does It Matter?

8:00 AM - 10:15 AM/Room: Mile High Ballroom 4A
Leader/Moderator: Natalie A Bratcher
Facilitator: Sara R Oglesby

Those involved with caring for and engaging animals as an essential part of research support the growing need for the 3Rs and alternatives. The culture within our industry has rapidly evolved and many are going above and beyond regulations and guidelines to implement 3Rs, which will ultimately lead to more impactful science and improved animal welfare. Over the years, animal rights (AR) groups have attempted to characterize animal research as useless and restrict the ability of research organizations to work with animals in science through various initiatives and agendas. As these groups become more strategic in their efforts, they are rebranding the 3Rs through the AR lens and using shared platforms, such as science consortia and grant programs, to attempt to ground and inaccurately legitimize existing alternative technologies as full replacements for animals in research currently. This must not distract us from the power the 3Rs have to provide a framework for developing more humane and predictive research strategies. Concurrent with our investment in the 3Rs, animals continue to play a crucial and necessary role in advancing biomedical progress and our ability to produce life-changing healthcare products. While research organizations are making significant advances in the 3Rs, they are often prevented from sharing these advances with the public because of a reflexive fear to embrace transparency that is based on AR threats of the past. We will discuss why it is critical that we be allowed to share our 3Rs advances as a platform for educating the broader public about why animals are still necessary in basic and applied research. This seminar will cover why it is critical that we become more transparent in sharing impactful 3Rs efforts as well as educating the broader public about where animal research is necessary. Participants will get to engage in thoughtful discussion about how why we need to step up as an industry to lead the messaging and how to overcome barriers to transparency. This seminar is for anyone involved in laboratory animal research.

Speakers/Topics:

8:00Natalie A BratcherWelcome
8:05Dino M BradleyIntroductions
8:10Natalie A BratcherThe Current 3Rs Landscape
8:30Jim NewmanThe State of 3Rs Research and Remits of the Opposition Groups
8:50Thomas LeachThe Bioscience Initiative
9:10Jennie LofgrenWhat Does Effective Transparency Look Like?
9:30Cindy A BuckmasterThe Importance of In Reach, Outreach, Transparency, and Why We Need to Do More
9:50All PresentersDiscussion

This Seminar is sponsored in part by Institutional Officials Consortium (IOC), Americans for Medical Progress (AMP), and The Bioscience Initiative.

Zebrafish Husbandry and Veterinary Care: One Health Based on Many Small Fish
8:00 AM - 10:15 AM/Room: Mile High Ballroom 3A
Leader/Moderator: Monte Matthews
Facilitator: TBN

The zebrafish (Brachydanio rerio) is an important model animal widely used in basic and biomedical research. As our understanding of the biology and genetics of the zebrafish increases, so does our appreciation of their value as a model of human health and disease. Zebrafish offer a unique, cost-effective means to study many of the critical issues of our time—environmental toxins, emerging infectious diseases including zoonoses, and behavioral and mental health issues, thus positioning them as a key in the One Health approach. The expanding scope and scale of zebrafish science demands a more robust and sophisticated approach to assessing and improving husbandry in aquatics facilities to reduce disease burden and increase animal health and welfare. We need to improve our understanding of the impact of core husbandry applications, such as social housing and environmental enrichment on the zebrafish model. As we elucidate and implement practices that improve reproducibility by enhancing normal behaviors and reducing stress and disease, we will discover myriad ways that zebrafish may further contribute to the search for solutions in emerging human diseases, environmental issues, and health issues of other aquatic species as well. We will explore ways to translate and incorporate standard lab animal husbandry techniques in zebrafish facilities. The audience will learn how to apply familiar husbandry methods such as body condition scores, health assessments, and social housing to zebrafish facilities. We will describe the intertwined husbandry and veterinary care components. Finally, we will discuss the advantages, limitations, and integration of improved environmental monitoring and ante mortem samples for zebrafish quarantine and colony health monitoring. The target audience is managers, technicians, and veterinarians.

Speakers/Topics:

8:00Monte MatthewsWelcome and Introductions
8:10Christian LawrenceHusbandry and Management: Moving Towards One Health?
8:35Kathleen SnellSocial Housing and Environmental Enrichment in Zebrafish: Improving Animal Health and Study Reproducibility
8:55Lauren PandolfoHow Body Condition Scoring, Standardized Health Assessment, and Sentinel Monitoring Can Reduce Disease Burden in a Large- Scale, Non-SPF Facility
9:20Tannia ClarkHealth Assessment of Individual Fish in Tanks: The Initial Step in Diagnosis and Treatment
9:45Marcus J CrimStrategies for Comprehensive Zebrafish Colony Health Monitoring and Quarantine

PLATFORM SESSIONS

8:00 AM-10:45 AM

Platform Session abstracts will be available on www.aalas.org in July. They will also be included in both the mobile app and the National Meeting Final Program.

SPECIAL TOPIC LECTURES


Animal Ethics, Animal Ideology, and the Defense of Animal Research: Why Appealing to Science and the Benefits of Research Have Not Been Working

11:00 AM - 12:00 PM/Room: Mile High Ballroom 1A
Speaker: Jerrold Tannenbaum
Moderator: B Taylor Bennett
Facilitator: Alissa Hatfield

In recent years the research community has mounted increasingly sophisticated and well-argued defenses of the need for the use of animals in biomedical research. These defenses have focused on the scientific necessity of animal use in the understanding of disease, and on demonstrable and predictable benefits of animal research for human and animal health. However, these defenses of animal research have had limited success. Attempts to use the legal system, in the courts and in state and national legislative and regulatory bodies, to severely curtail and eventually terminate animal research are on the rise. Public opinion supporting animal research has not been overwhelming and in fact appears to be diminishing slowly but surely. This presentation will explain why appealing to science and the benefits of animal research have not been working—and cannot work—unless and until the research community appreciates developments and trends in the field of animal ethics. The presentation will explain how opponents of the use of animals to benefit humans and animals have come to dominate discussions of animal research ethics and are turning academics, lawyers, judges, legislators, college students, and members of the public against animal research. As will be discussed, successive theoretical ethical approaches to animal use have diminished the importance of facts and science in discussions of animal research and other human uses of animals. An ideology has been established that diminishes the value of or is impervious to appealing to demonstrable facts and sound science in defending animal research. Thus, the kinds of arguments the research community has been making in favor of animal research are striking an increasing number of people as unimportant or irrelevant. The presentation will suggest several ways in which the research community might counter this ideological, anti-empirical approach to animal research. The target audience will be all who are involved in animal based biomedical research.

This Special Topic Lecture is sponsored in part by National Association for Biomedical (NABR).

Nathan E Brewer Lecture:

11:00 AM - 12:00 PM/Room: Mile High Ballroom 2A
Moderator: Ann L Murray
Facilitator: TBN

Speaker and description will be available after the Award Selection Committee selects the Nathan Brewer Award recipient. This session information will be available in the mobile app and in the Final Program.

This Special Topic Lecture is sponsored in part by AALAS Awards Selection Committee (ASC).

The Pediatric Neurocysticereosis Crisis in Rural Sichaun: Time for a One Health Approach to Tibetan-Bacon-Makin'

11:00 AM - 12:00 PM/Room: Mile High Ballroom 4A
Speaker: Stephen A Felt
Moderator: Jennifer Asher
Facilitator: TBN

Infection with the zoonotic tapeworm Taenia solium affects millions of people living in poverty throughout Asia, Africa, and Latin America. Considered a neglected tropical disease, infection is linked to inadequate sanitation and hygiene, presence of free-roaming pigs, and poverty. Infection in humans has two manifestations: intestinal taeniasis where humans serve as the definitive hosts for the adult tapeworm which inhabits the gastrointestinal tract, and cysticercosis, a tissue infection where humans are the accidental dead-end host for the cystic larvae (cysticercus). Intestinal infestation with the adult tapeworm develops when humans consume improperly cooked pork containing cysticerci. Neurocysticercosis (NCC) develops when T. solium larva establishes itself in the CNS and may lead to morbidity which can be fatal. NCC causes a range of symptoms depending on number, stage of involution, volume, and location of the lesions, including seizures, chronic headaches, focal neurological deficits, psychiatric disturbances, and cognitive impairment. This talk will transport the audience to the remote mountain villages of Sichaun, China, where our interdisciplinary, international, One Health team (Stanford University, University of Sichuan School of Public Health, Sichuan Agricultural University, Centers for Disease Control and Prevention- China) have been working since 2016 to elucidate this parasite's epidemiology with the ultimate goal of developing and deploying pig-, people-, and environment-focused strategies to ensure its eradication. This lecture is appropriate for all attendees, including veterinarians, IACUC members, compliance and safety officers, and researchers. It may be of particular interests to those individuals who currently have or are considering developing One Health-focused international research projects.

Zoognosis: Understanding The Knowledge We Share

11:00 AM - 12:00 PM/Room: Mile High Ballroom 3A
Speaker: Claire A Simeone
Moderator: Trinka W Adamson
Facilitator: TBN

Zoonotic diseases like rabies impact both animal and human health. Research to understand zoonoses and mitigate their impacts dominates the One Health movement, yet the connections between us run much deeper than diseases we share. This topic is targeted toward scientists, clinicians, and professionals interested in exploring the One Health topic in an alternative way. Marine mammals are sentinels of the sea. From new treatments for corneal ulcers, to the way a starving seal in California can help a starving seal in Hawaii, to the secrets a seizing sea lion holds, marine mammals can shout calls of alarm, if we are willing to listen. Dr. Claire Simeone is Hospital Director of Ke Kai Ola, the Marine Mammal Center's hospital dedicated to the conservation of the endangered Hawaiian monk seal. Dr. Simeone will take you on a journey to learn how marine mammal medicine, physiology, and behavior can inform our understanding of our own health, and the balance between wildlife conservation, ocean conservation, and the human species' very survival.


WEDNESDAY AFTERNOON

PANEL DISCUSSIONS


A First Responders Worst Nightmare: Your Vivarium
12:30 PM - 2:00 PM/Room: 401
Leaders: Tasha M Thomas, Mark E Moore
Moderator: Ann L Murray
Facilitator: TBN
Panelists: Tasha M Thomas, Mark E Moore

As a member of the vivarium leadership team, one of your core responsibilities is to protect your staff, animals, and infrastructure in the event of an emergency, particularly a natural disaster. The implementation of an emergency management plan consists of many components that include but are not limited to identified essential emergency team members and emergency supplies for both the animals and staff. The presenters will review standard best practices for emergency preparedness, introduce the need for local and state collaboration for the best possible outcome, and share additional post emergency resources. A Deputy Emergency Manager and Executive Officer to the Fire Chief with the Division of Emergency Management will share tips on facilitating the dialogue with your local first responders, identify who you need to reach out to, questions to ask, what to share, and how to ensure you will be well supported in the event an emergency occurs. The presenters will also provide an overview of the pros and cons of implementation and share what a realistic and ideal relationship between an animal facility and local emergency management should look like. The panel will cover an introduction to emergency management principles, first responder’s worse fears, tools and tips for engaging key local and state resources, and novel resources in the aftermath of a natural disaster such as drone coverage. The seminar presenters are based in Florida and will focus on natural disasters such as flooding, tornadoes, and hurricanes. The panel discussion will allow participants to discuss the advantages of the emergency management model recommendation. The targeted audience is directors, facility managers, supervisors, and facility leadership.

A Future with Marmosets: Understanding the Numbers

12:30 PM - 2:00 PM/Room: 403
Leader/Moderator: Patricia V Turner
Facilitator: Lida Anestidou
Panelists: Monika A Burns, Margaret S Landi

The common marmoset (Callithrix jacchus) has become a much sought primate model of disease both in the United States and globally. A number of activities in the past months (for example, the NHP Evaluation and Analysis efforts by NIH’s Office of Research and Infrastructure Programs; a community-led principal Investigator meeting; and the ILAR Roundtable workshop on the Care, Use, and Welfare of Marmosets) have highlighted the importance of the species and brought to the forefront the struggle to maintain adequate numbers of marmosets in captivity for research purposes while safeguarding their genetic diversity and respecting the efforts to protect marmosets in the wild. This panel will engage the audience in a robust discussion of the key aspects that should inform the research community’s strategic approach to ensuring adequate supply of captive marmosets. There will be a discussion on establishing a balance between maintaining the wild populations of marmosets in Latin America and the need for robust colonies of captive marmosets. Dr. Burns will lead a discussion on assessing the future needs of research with marmosets. Dr. Landi will focus on the unique ethical issues of research using marmosets. The targeted audience is veterinarians; researchers; IACUC members and administrators; institutional officials; government officials; and policy professionals. The participants will learn about the different viewpoints informing the efforts to procure and maintain adequate numbers of marmosets for research.

This Panel Discussion is sponsored in part by Institute for Laboratory Animal Research (ILAR) and Association for Primate Veterinarians (APV).

Change Is Coming: Updates to the AVMA Panel on Euthanasia

12:30 PM - 2:00 PM/Room: 501
Leader: Debra L Hickman
Moderator: Natalie A Bratcher
Facilitator: Beth A Skiles
Panelists: Samuel C Carter, Emily G Patterson-Kane, Natalie A Bratcher, Kathleen R Pritchett-Corning

The AVMA is in the process of updating the AVMA Guidelines on Euthanasia, with special emphasis on updates to the requirements for CO2 for laboratory animals. Euthanasia remains one of the most important aspects of laboratory animal welfare. In this session, we will review the changes and discuss ways for institutions to implement the changes. In addition, data supporting these changes and how to best implement them for optimal welfare will also be discussed. The target audience is anyone interested in learning about and discussing euthanasia and animal welfare refinement; those using euthanasia methods in rodents; scientists, technicians, and veterinarians; and IACUC members and facility managers.

The IACUC Role in Veterinary Clinical Trials

12:30 PM - 2:00 PM/Room: 503
Leader/Moderator: Lon V Kendall
Facilitator: TBN
Panelists: Lon V Kendall, Valerie K Bergdall, Philippe J Baneux, Rodney Page, Nicolette A Petervary, USDA representative TBN

Veterinary patients often provide natural models of human disease, and novel therapies in veterinary medicine provide further insight into human health. These therapies may be experimental, using existing treatments in novel applications or novel treatments for existing diseases. This session will highlight how institutions may approach oversight and management of clinical trials in veterinary patients. The role of the IACUC will be discussed and when it is appropriate for IACUC oversight. The role of the veterinary clinical studies committee (as defined by the AVMA) will also be discussed and when it is appropriate to have VCSC oversight. This session will be beneficial to IACUC members and administrators, veterinarians, institutional officials, and members of the scientific community.


WORKSHOPS


W-15 An Interactive Comprehensive Decontamination Experience: From Analysis to Understanding to Application

1:00 PM - 5:00 PM/Room: 302
Leaders/Faculty: Christine Greene, Frances M Grinstead, Dan Ghidoni
Facilitator: Richard Mullen
Workshop Fee: $150 Workshop Limit: 50

During this workshop attendees will gain an understanding of several aspects of proper decontamination. Learn from experts in the field of microbiology, environmental decontamination, and from laboratory equipment specialists to overcome challenges facing effective facility decontamination. The workshop’s goal is to empower participants with the knowledge and first-hand experience to create and maintain healthy spaces. Presented in 3 segments, the workshop will explore surveillance methods and validations, foundations of cleaning and disinfecting, and decontamination applications. Participants will learn to distinguish the difference between diverse types of validation methods to determine the safety of a space in regard to contamination. Also, participants should gain a thorough understanding of chemical decontamination in order to select proper fact-based solutions centered on needs rather than marketing. Finally, participants will learn techniques to Implement easy protocols for complete decontamination and protect research, staff, and animals to create a healthy environment with solutions rooted in science. This workshop is essential for all vets, facility managers, and technicians.

This Workshop is sponsored in part by Baker Company, CURIS(R) System and NSF.

W-16 Gnotobioic Isolators 101

1:00 PM - 5:00 PM/Room: 301
Leaders/Faculty: David Holland, Maureen A Bower, Josh Frost
Facilitator: Stephanie W Fowler
Workshop Fee: $150 Workshop Limit: 50

Gnotobiotic Isolators 101 is an entry-level workshop on isolators used with gnotobiotic rodents. The workshop will provide information on what an isolator is, the types of isolators available, components of an isolator, and basic operational procedures of isolators. The workshop will include hands-on training with an isolator system and working with an isolator. Hands-on work will include preparing filters and sterilizing cylinders, assembly of an isolator, sterilizing an isolator, sterility testing, and transferring items into and out of an isolator.

This Workshop is sponsored in part by Class Biologically Clean, Ltd., University of North Carolina and The Association for Gnotobiotics, Inc.

W-17 IACUC Challenges: Real-Life Case Studies and Issues

1:00 PM - 5:00 PM/Room: 304
Leaders: Marcy A Brown, Deborah A Frolicher
Faculty: Marcy A Brown, Deborah A Frolicher, Eileen M Morgan, USDA Representative TBN
Facilitator: Jane Chambers
Workshop Fee: $150 Workshop Limit: 50

This popular workshop uses a mixture of case studies, group discussion, and interactive exercises to identify best practices for resolving real-life IACUC challenges or issues. Attendees should have a working knowledge of the regulations, guidelines, and policies associated with animal care and use programs. Faculty includes certified IACUC professionals, as well as representatives from OLAW and the USDA. Participants will work in small groups to discuss challenges and case scenarios. Faculty will interact with individuals and groups to assist them in developing methods to deal with difficult situations involving the IACUC. Situations likely to be discussed include pain/distress categories, humane endpoints, rationale for species and numbers of animals, noncompliance and investigations, difficult investigators, high-risk animal models, how to implement and use veterinary verification and consultation (VVC), and training issues. Prior to the workshop, attendees will be able to anonymously submit their own real-life challenges or issues for group discussion. The targeted audience includes veterinarians, IACUC members (including nonaffiliated members), post-approval monitoring staff, trainers, animal technicians, investigators, and investigative staff members.

W-18 Technician to Supervisor, Management 101

1:00 PM - 5:00 PM/Room: 303
Leader/Faculty: Stephen T Baker
Facilitator: N/A
Workshop Fee: $150 Workshop Limit: 50

When you excel at a technical skill or provide superior husbandry/support, individuals are often rewarded with a promotion that expands their role and responsibility to include managing others. Individuals whose primary focus/expertise are animals are asked to change gears and channel their soft skills. This workshop will provide an overview/introduction of key competencies to support a successful transition. Topics will include performance management, effective communication, how to handle conflict, coaching versus delegating, and what it means to be a leader. This interactive workshop will take participants through various exercises, role plays, and what-if scenarios to provide take-aways that can be applied back at their place of employment. The targeted audience includes, new supervisors, or first-level managers. If you are new to the world of managing others or contemplating getting into management, you do not want to miss this workshop.

W-19 Working with Difficult Personalities: How to Survive and Thrive

1:00 PM - 5:00 PM/Room: 612
Leaders/Faculty: Laura A Conour, Pamela A Straeter
Facilitator: Misty J Williams-Fritze
Workshop Fee: $150 Workshop Limit: 50

Do you have a PI, colleague, or employee that you just dread working with? Is your day ruined when you see this person looming in the door of your office and stomping into your personal space? Have you tried deep breathing exercises but still find yourself grinding your teeth after a totally nonproductive encounter? Are you starting to ask yourself, "Is it me?" If you answer "yes" to even one of these questions, then this workshop should appeal to you. Take charge of the situation and learn how to manage these interactions in a manner that keeps you from screaming and doesn't ruin your workday. This workshop is structured for managers and directors of laboratory animal care and compliance departments. Using a combination of didactic learning, case studies, and role-playing scenarios, we will present you with the tools needed to recognize the personality type of individuals that are challenging to interact with and strategize how to manage these interactions such that they are constructive, productive, and structured in a manner that preserves your sanity. Workshop attendees should come prepared with their own examples of challenging interactions and be prepared to participate in this highly interactive workshop.


PLATFORM SESSIONS

2:15 PM-5:15 PM

Platform Session abstracts will be available on www.aalas.org in July. They will also be included in both the mobile app and the National Meeting Final Program.

SEMINARS


Are Your NSG Mice Feeling NSG (Not So Great)? Disease Conditions in Humanized Mouse Models
2:45 PM - 5:00 PM/Room: Mile High Ballroom 2A
Leader/Moderator: Robert S Livingston
Facilitator: Crysti Reed

Mice used to create models of human immunobiology have mutations in multiple genes to allow engraftment of human cells. These altered genes—NOD; Prkdc scid or Rag1/Rag2; and IL2 receptor gamma (IL-2rg)—result in a lack of mature T, B, and NK lymphocytes, hemolytic complement activity, and diminished macrophage and dendritic cell functions. The severely immunodeficient state also renders these mice susceptible to spontaneous infections with microbial agents that otherwise do not colonize or cause clinical disease in immunocompetent mice. These infections can be severe enough to cause death, and if not lethal, may interfere with the use of data from infected mice. The overall outcome is loss of valuable research animals, time, and effort when affected mice cannot be used for studies. This seminar will provide information about possible sources of microbial contamination with a goal of reducing unwanted exposures during husbandry practices and experimental procedures. The targeted audience is laboratory animal veterinarians, facility managers, and husbandry and research personnel.

Speakers/Topics:

2:45Robert S LivingstonWelcome and Introductions
2:55Marcia L HartOpportunistic Viral Infections: Of Mice and Men
3:25Robert S LivingstonIt’s Not Easy Feeling Wheezy
3:55Cynthia L Besch-WillifordI Just Have a Gut Feeling
4:25Marcus J CrimOpportunistic Invasion in Microbial Warfare
4:55Marcus J CrimSummary

European-standard Housing and Procedures: Practicalities, Benefits for Animal Welfare, and Quality of Scientific Data

2:45 PM - 5:00 PM/Room: Mile High Ballroom 3A
Leader/Moderator: Helen Prior
Facilitator: Emma Stokes

The quality of housing and husbandry for laboratory animals has a major impact on their health and welfare. Environments that do not meet animals' physical, behavioral, and/or social needs can result in physiological changes and abnormal behavior that compromise welfare but may also influence the validity and reproducibility of scientific data obtained. While facilities meet minimum standards of accommodation and care as defined by national/regional guidelines, these standards vary internationally. Many facilities wish to adopt higher standards than those mandated by law, while some companies and research funders insist on EU standards, wherever the work is conducted. Studies are frequently outsourced to academic groups or contract research organizations (CROs). Some U.S. facilities have rooms equipped to EU standards, but demand can outstrip supply. Work may be sent outside the U.S. to access more EU-standard facilities, which adds logistical complexity (communication/monitoring visits, sample shipments, for example). U.S. facilities successfully running studies to EU standards are building experience in the benefits for both animals and staff, without compromising the science. This seminar will describe US- and EU-style housing and procedures, linking scientific benefits to animal welfare. An industry perspective will explain requirements for EU-standard studies, providing case studies highlighting the advantages and disadvantages. Speakers from a CRO and an academic research institution, both running studies to EU standards within the U.S., will provide practical information on animal management and training of staff. There will be an opportunity for audience members to share their experiences and ask further questions. The target audience is technicians, veterinarians, and scientists from academia and industry wishing to learn more about running studies to EU standards and the practicalities. CROs will be interested to learn about the drive to run more studies to these standards, and thus the potential market available now and in the future.

Speakers/Topics:

2:45Helen PriorWelcome and Introductions
2:50Mark J PrescottChoosing Contractors for Large-animal Preclinical Studies: Addressing Variation in Welfare Standards
3:15Noel DybdalIndustry Perspective for Studies to EU Standards
3:40Simon AuthierCRO Perspective for Studies to EU Standards
4:05Paul KievitSize Matters: EU-style Cages for NHP Research in the Academic Environment
4:30Helen PriorDiscussion

Extrinsic Factors that May Impact Animal Models and Study Reproducibility

2:45 PM - 5:00 PM/Room: Mile High Ballroom 4A
Leader/Moderator: Neil S Lipman
Facilitator: Alicia Donnelly

There has been considerable discussion in recent years about enhancing the characterization of animal models to ensure greater scientific and translational relevance. An increased focus on the optimization of animal models and a heightened awareness of the value of robust study design provide opportunities to address potential confounding factors and sources of bias. These efforts can facilitate the improvement of animal research studies by fostering increased scientific rigor and experimental reproducibility. One recent initiative is an upcoming ILAR Journal issue dedicated to the examination of extrinsic factors that can potentially impact animal models and influence study outcomes. Panel members will present high-level overviews of various extrinsic factors, and how these variables might be addressed during study design and reporting. The object of the session is to promote discussion within the greater research community about extrinsic factors commonly encountered in animal-based research studies. A greater understanding of extrinsic factors and how to effectively address these variables during study design should enhance preclinical study reproducibility, and benefit both lab animals and human patients. Attendees will learn how extrinsic environmental factors can have an impact on animal models and influence experimental outcomes. In addition, participants will learn about approaches to enhance scientific rigor and study reproducibility. The discussion will have relevance for research biologists, lab animal scientists, laboratory animal medicine practitioners, and veterinary pathologists.

Speakers/Topics:

2:45Neil LipmanWelcome and Introductions
2:55Cory F BraytonExtrinsic Factors: Reproducibility in Science
3:15John J HasenauHousing Systems and Husbandry: Terrestrial Models
3:35Debra L HickmanSocial and Behavioral Considerations: Terrestrial Models
3:55Scott PerkinsXenobiotics: Terrestrial models
4:15Neil LipmanDiscussion

One Health Approach for the Animal Caregiver: Occupational Health, Human-Animal Bond, and Compassion Fatigue

2:45 PM - 5:00 PM/Room: Mile High Ballroom 1A
Leaders: Sally Thompson-Iritani, J Preston Van Hooser
Moderator: Sally Thompson-Iritani
Facilitator: TBN

This session will introduce the One Health approach for care and education of animal caregivers. Topics introduced and discussed will include the human-animal bond, training and education regarding emotional involvement, preventative care for personnel, occupational health tools for prevention, and monitoring and updates on national and international efforts to develop programs for support. There will also be a summary from the ILAR roundtable on the topic that is scheduled for Fall 2019. Participants will learn information about the relationship between people, animals, and the environment and how it impacts our animal care and use programs. Topics discussed and defined will include human-animal bond, compassion fatigue, burn-out, occupational health prevention, and the important role that each of us can play by recognizing and supporting programs at our institutions. The target audience is animal caregivers includes husbandry, technicians, researchers, IACUC members, and any personnel that may be involved with the care and oversight of animals in a research setting.

Speakers/Topics:

2:45Sally Thompson-IritaniWelcome and Introductions
2:50Lesley SharpCreative Compassion in Human-Animal Care: An Outsider Looks in on Lab Life
3:15Bruce W KennedyThe Human-Animal Bond: Summary of the NAS/ ILAR Roundtable
3:40Anneke KeizerNeeds Assessments: Common Themes and Suggestions for Consideration
4:05Christina Pettan-BrewerOne Health Approach: Incorporating Prevention into Your Occupational Health Program
This Seminar is sponsored in part by Dare 2 Care - Compassion Fatigue Committee and COPEPLUS.