Wednesday Morning


W-13 Advanced Techniques in Gnotobiotics
8:00 AM - 12:00 PM/Room: 5A
Leader: Julia R Krout
Faculty: Stephanie Fowler, Christina M Olivares, Alton G Swennes, Betty R Theriault
Facilitator: Stephanie M Cormier
Workshop Fee: $140 Workshop Limit: 50

This workshop is designed to provide advanced technical perspective in gnotobiotics. Participants that possess a basic understanding of flexible film isolators, semi-rigid isolators, or bioexclusion ventilated rack systems will learn advanced techniques that are essential for long-term facility operation. These include isolator component replacement and repair, equipment maintenance, transfer and shipment of animals, the use of non-standard diets and supplies, colony management, and alternative housing methods. The workshop will feature hands-on work in a variety of equipment used in gnotobiotics. This workshop targets those who have a basic understanding of gnotobiotic animal husbandry and wish to learn advanced techniques that are essential for long-term facility operation. Also, the workshop will introduce attendees to the variety of equipment options available. Presenters will guide workshop attendees through the following advance technical procedures and provide perspective.

This Workshop is sponsored in part by Allentown, Charles River, Class Biologically Clean, Taconic and Tecniplast.

W-14 Animal Facility, Design, Processes, Decisions, and Technology
8:00 AM - 12:00 PM/Room: 4B
Leader: Mark A Corey
Faculty: Mark B Gold, Laura Halverson, Lauri Tyrrell, Katie L McGimpsey
Facilitator: TBN
Workshop Fee: $140 Workshop Limit: 50

This session will benefit those involved with animal facility design and operations by describing the process, decisions, and technologies involved in the design, construction, and management of animal facilities. The workshop will begin with a discussion of the facility design process, who should be involved, the objectives and level of effort by stakeholders, milestone decisions to be reached, and anticipated durations of the various phases of the process. Next, current trends in the industry will be explored through discussions about planning, interior construction, and finishes. Next, we will present a case study about creative facility solutions for housing large animals, including an open discussion comparing EU and AWA regulations for these kinds of facilities. Lastly, we will discuss mechanical, electrical, and piping design and operations. The discussion will focus on the risks associated with animal welfare, loss of research and facility resiliency, and how engineering decisions affect each of these parameters. These lessons learned will help enable participants to make more informed decisions as they develop and operate their own facilities. Finally, planning energy and resource efficient facilities is no longer a trend or an option, but rather an integral driver in facility planning. We will discuss sustainability strategies regarding energy and water that are being effectively implemented in animal facilities and the long-term benefits derived from each.

W-15 Innovative Ways to Incorporate Lean Tools and Concepts into Routine Facility Processes
8:00 AM - 12:00 PM/Room: 7
Leader: Gerry M Cronin, Julieanne Brandolini
Faculty: Angie Heiser, Titilayo Lamidi, Amy Mikkola, Ashley Stamatis
Facilitator: Caroline R Warren
Workshop Fee: $140 Workshop Limit: 50

The Center for Comparative Medicine (CCM) at Massachusetts General Hospital (MGH) supports biomedical research across multiple campus locations and species. In an effort to build and support an innovative continuous improvement (CI) culture, we empower staff to find opportunities to improve processes. Increased effectiveness and efficiency, in turn, impact both staff and animal welfare in a positive way. CCM began a lean journey 12 years ago and in 2013, formed a Continuous Improvement Steering Committee (CISC) tasked with identifying gaps in the lean program. Due to the complex work environment we identified lean knowledge training as a challenge that affected our CI culture. Our countermeasure was to use interactive technology and adapt games to engage staff and foster our CI culture. In doing this, we have been able to integrate CI concepts into our daily animal care schedules rather than having to carve out time for lectures or workshops. To ensure that measurable improvements were made, surveys were distributed to staff before and after this initiative. Scores demonstrated a 19% increase in lean knowledge across the department, including a marked increase in scores attained by employees in their first 6 months. This indicated that we were successful in enhancing staff’s understanding of our CI concepts simultaneously with their animal care training rather than as an afterthought. Attendees will experience interactive teaching practices that make learning lean or any process fun. These exercises are easily accomplished as a team, in the work area, and in a short period of time. Topics to be addressed include, accelerating a CI program with a steering committee, developing rapid learning techniques, engaging staff and reinforcing team culture, and collecting metrics to show increased knowledge.

This Workshop is sponsored in part by Massachusetts General Hospital Center for Comparative Medicine.

W-16 LAS Pro Article Writing Boot Camp
8:00 AM - 12:00 PM/Room: 8B
Leaders: John Farrar, Liz Rozanski
Faculty: Chris Boehm, Andrew Burich, Bob Dauchy, Penny Devlin, Jamie McClellan, Elizabeth Nunamaker
Facilitator: TBN
Workshop Fee: Free Workshop Limit: 50

Laboratory Animal Science Professional (LAS Pro), the flagship AALAS publication, features articles highlighting the latest developments and strategies in our field, as well as technician tips and feature stories on the diverse professionals who work in our field. Do you want to be a part of your association’s magazine? Bring your concepts or an article outline and we will help you get started down the road to publication! The magazine’s Editorial Advisory Board will be on hand to offer encouragement and expert advice. The targeted audience for this workshop is any AALAS member looking to publish, particularly those who have not published previously. Participants are encouraged to bring their own laptops to the session.

This Workshop is sponsored in part by AALAS.


A Change in Climate Can Lead to a Better Safety Culture
8:00 AM - 10:15 AM/Room: Ballroom F
Leader/Moderator: Larry J Shelton
Facilitator: Donna L Goldsteen

Laboratory animal research presents unique hazards pertaining to worker safety. Often, unsafe conditions are not discovered until an injury occurs and in most cases, the injury could have been prevented had someone informed the staff or safety team of an at-risk condition or a near miss. Most observations go unspoken due to fears of repercussions. In an effort to cultivate the safety climate in animal facilities and encourage proactive rather than reactive reporting, laboratory animal research (LAR) groups should partner with safety health and environment (SHE) groups to take a behavioral-based approach to safety. A primary focus is to measure the performance of culture, rather than the absence of injury. These partnerships focus on promoting safe behaviors within the working environment, increasing the reporting of near misses and at-risk conditions/behaviors, and encouraging employee participation in safety awareness while further evaluating technical and husbandry procedures. The initiatives are further encouraged through participation and transparency of management and by incorporating safety components into the overall goals of the LAR groups. The speakers on this panel will discuss how a behavioral-based approach to safety works in various LAR environments. We will discuss the successes in our own LAR programs following implementation of such a program. Target audience includes facility directors, facility managers, technical staff, and IACUC administrators.


8:00 Larry J Shelton Welcome and Introductions
8:10 Jonathan Harris Creating a Culture of Safety: A Behavior-Based Approach
8:30 Erin Straley Behavioral-Based Safety: An Industry Perspective
8:50 Marisa St Claire Behavioral-Based Safety: A BSL3/BSL4 Perspective
9:10 April ClaytonThe ABCs of Lab Animal Biosafety Risk Management: Attention to Human Behavior to Curb Risk and Enhance Animal Care
9:30 George W Lathrop, Jr Behavioral-Based Safety: A Government Perspective

Corynebacterium bovis
in Immunodeficient Rodent Colonies: Current Landscape in Detection, Routine Surveillance, Treatment, and Control Strategies
8:00 AM - 10:15 AM/Room: 9B
Leader/Moderator: Nicolette A Zielinski Mozny
Facilitator: TBN

Corynebacterium bovis continues to have an impact on scientific programs working with severely immunodeficient rodent colonies. C. bovis is primarily associated with athymic nude mice but is an opportunistic pathogen of other immunocompromised strains such as haired SCID and NOD scid gamma mice. Pervasive contamination of the environment and common use equipment is known to perpetuate the infection and slow efforts to eliminate this pathogen. Increased scrutiny of biologics, such as tumor tissue, has recently been reported as a source of reintroduction of C. bovis. Traditional isolation by culture and the more recent PCR applications are important tools for C. bovis screening. Correct sampling, sentinel programs, and biologics testing will impact the effectiveness of an exclusion and surveillance program. Once C. bovis is detected in your facility, discussions on how institutions work with this information to create informed program decisions for treatment and eventual eradication will be addressed. The participants will learn about current strategies to detect, treat, and control C. bovis from the perspective of an international diagnostic laboratory and three academic institutions. Overlapping stories will focus on surveillance programs and decontamination practices, as well as treatment and control. The target audience for this session is any academic or industrial institution working with immunodeficient rodents. This includes research scientists and the veterinary and husbandry teams involved in the operations of a vivarium.


8:00 Nicolette A Zielinski Mozny Welcome and Introduction
8:10 Nicolette A Zielinski MoznyCorynebacterium bovis in Immunodeficient Rodent Colonies: Current Landscape in Detection, Routine Surveillance, Treatment, and Control Strategies
8:20 Kenneth S Henderson Methods to Exclude and Monitor for Corynebacterium bovis
8:40 Chris A Manuel Corynebacterium bovis Remediation: The Fight Is at the Room Level
9:00 Keely L Szilágyi It’s a Hairy Situation: Maintaining Corynebacterium bovis-free Haired Immunocompromised Mice
9:20 Nicolette A Zielinski Mozny Now You Have Corynebacterium bovis: What Are Your Next Steps?

Refining the Use of Laboratory Rodents: New Approaches to Improve Animal Welfare and Scientific Outcomes
8:00 AM - 10:15 AM/Room: 18B
Leader: Mark J Prescott
Moderator: Samuel Brod
Facilitator: Emma Stokes

Rodents are by far the most commonly used animals in research. Techniques developed to improve the welfare of these animals can therefore have a large impact within the scientific community. Implementation of refinement opportunities is also important from a scientific perspective, because animals with compromised welfare have disturbed behavior and physiology, which can lead to unreliable conclusions and/or unwanted variation in scientific output, affecting the reliability and repeatability of experiments. Throughout 2017, the NC3Rs is highlighting new technologies and approaches for improving the welfare of mice and rats and for optimizing scientific outcomes, as part of our "year of laboratory rodent welfare." This seminar will present four such advances, developed with NC3Rs funding, ranging from a bespoke system for continuous 24/7 monitoring of the location and activity of individual rodents housed socially in the home cage, to refined methods of handling mice which reduce mouse anxiety and stress and improve performance on behavioral tests. A discussion session will allow for questions between the speakers and audience, and delegates will be provided with printed resources to help raise awareness of some of the refinement opportunities within their research facilities. We encourage scientists, veterinarians, and animal care staff to attend the seminar to learn about new opportunities to refine the use of laboratory mice and rats, and to expand their knowledge of the link between good animal welfare and good quality science.


8:00 Mark J Prescott Welcome and Introduction
8:05 Sara E Wells Automated Monitoring of Mouse Behavior in Social Home Cage Groups: What Happens When You Are Not Looking?
8:35 Jane Hurst Optimizing Reliability of Mouse Performance in Behavioral Testing: The Major Role of Non-Aversive Handling
9:05 Michael Emerson A New Mouse Model of Pulmonary Embolism: Major Refinement and Improved Clinical Relevance
9:35 Mark J Prescott Opportunities for Improving Animal Welfare in Rodent Models of Epilepsy and Seizures
10:05 All Discussion

Updates on Rodent Thermoregulation: Is It Hot In Here or Is It Just You?

8:00 AM - 10:15 AM/Room: Ballroom D
Leader/Moderator: F Claire Hankenson
Facilitator: TBN

Comprehension of the mechanisms, influences, and outcomes of rodent thermoregulation is critical for both scientific, husbandry, and veterinary professionals to best promote animal wellbeing and care. The body of literature continues to evolve regarding the benefits and challenges related to diminished and elevated individual and environmental temperatures on laboratory rodents. Common murine behavioral and physiological adaptations to cold stress within the context of the modern vivarium will be described, with emphasis on ventilated cages, nesting material, and stocking density. Next, challenges and benefits of maintaining rodent temperatures, both in the conscious and anesthetized mouse, will be reviewed. The thermal physiology of laboratory rats will then be discussed, including autonomic and behavioral responses, with emphasis on restraint stress and caloric restriction. Finally, the seminar will emphasize the importance of documenting and describing aspects of environmental and experimental methods to bolster reproducibility and repeatability of rodent studies. The intended audience is scientists, veterinarians, veterinary technicians, and husbandry teams involved in the care and wellbeing of laboratory rodents.


8:00 F Claire Hankenson Welcome and Introductions
8:10 John M David Thermal Biology of Mice with Special Focus on Modern Vivaria
8:35 James O Marx The Whys and Hows of Keeping Anesthetized Mice Warm
9:05 Christopher J Gordon Thermal Physiology of the Laboratory Rat: Consequences of Stress
9:30 F Claire Hankenson Reproducibility: Can You Repeat That?

Special Topic Lectures

A Proposal for Noise and Vibration Standards in the Lab Animal Vivarium

11:00 AM - 12:00 PM/Room: 18B
Speaker: Jeremy G Turner
Moderator: Paige A Ebert
Facilitator: TBN

The Guide for the Care and Use of Laboratory Animals (8th ed) mentions the problems of noise 39 times and vibration 28 times. The Guide effectively warns us (facility managers, technicians, veterinarians and PIs) that noise and vibration in the research animal facility space can serve as stressors for the lab animals and potential confounds for research using them. However, the Guide offers no hard information about what levels of noise and vibration are normal or acceptable in the vivarium, nor how/whether such variables should be measured, making it difficult for those of us charged with caring for lab animals to know whether their environments are safe. In this presentation, we propose a series of noise and vibration standards, based on the scientific literature and our experience with these measurements in the animal facility environment, that can be used as guidance for animal facilities until the Guide is able to address them directly. Our proposal suggests levels of noise and vibration that are to be avoided, as they are expected to be harmful to animals, as well as various strategies for mitigating noise and vibration problems if they are found. Our proposal also suggests best practices for planning, measurement, and monitoring for construction activities in and around the animal facility.

Caretaker Behavior as an Influence on Nonhuman Primate (NHP) Welfare
11:00 AM - 12:00 PM/Room: Ballroom D
Speaker: Kate C Baker
Moderator: Maggie S Behnke
Facilitator: TBN

The role of NHP caretakers in behavioral management programs has expanded since the early 2000s. A larger proportion of facilities now involve caretakers in areas such as positive human interaction, positive reinforcement training (PRT), implementation of interventions for animals displaying abnormal behavior, and monitoring of social introductions. This is true even in large facilities, which are more likely to employ behavioral management departments and staff. This exciting development illustrates the increased integration of behavioral care into overall animal care. Caretakers are in a unique position to influence welfare. First, caretakers observe NHPs in different contexts from other employees, which may be pivotal for evaluating welfare and making decisions. For example, observations of social behavior during feeding are necessary for evaluating compatibility. Caretakers can also evaluate how well individuals respond to routine stressors. The success of a change in behavioral management may not be evident under quiet conditions, but may manifest in the contexts in which carestaff observe animals. Second, particularly for singly housed animals, caretakers are important outlets for expression of social behavior. Last, caretakers may engage in positive activities, such as feeding and providing enrichment, as well as those that could cause anxiety or distress (e.g. restraint, administration of injections). Amount of time exposed to caretakers and the mixed nature of caretaker activities suggest that optimizing caretakers’ behavior and interaction with the animals under their care should receive attention. Educating carestaff in PRT may introduce important principles into the management of NHPs. A number of steps are recommended to increase carestaff involvement, such as including welfare activities in job descriptions and performance reviews. Additionally, carestaff require significant training to perform these roles, including recognition of species-appropriate and abnormal behavior. This lecture aims to inspire managers, carestaff, and behavioral management departments to recognize that a well-trained team of caretakers can support strong behavioral management programs, and that both facilities and their NHPs will benefit from an expanded view of the nature of care and scope of the primate caretaker position.

This Special Topic Lecture is sponsored in part by American College of Laboratory Animal Medicine (ACLAM)/American Society of Laboratory Animal Practitioners (ASLAP) Program Committee.

Creating a Security Culture
11:00 AM - 12:00 PM/Room: 9B
Speaker: John J Sancenito
Moderator: Rachel R Strittmatter
Facilitator: TBN

This presentation will discuss how creating a security culture within a research organization can create a safer environment for employees, visitors, animals, property, and data. Physical security measures and security protocols are useless if they are not followed, yet employees regularly bypass or ignore them. Most security vulnerabilities are created by accident or ignorance, not malice. This allows for an organization to change these behaviors by incorporating security practices into daily routines. The following steps to creating a security culture will be discussed: effective security awareness training programs; communication and reinforcement of security concepts; embedding security principles into practices, policies, and procedures; empowering employees; and management support of security. The attendee will have a better understanding of crime prevention techniques, behaviors that put them and their organization at risk, social engineering/fraud scams, and things they can do to protect themselves, their families, and their workplaces.

Nathan E Brewer Lecture
11:00 AM - 12:00 PM/Room: Ballroom F
Speaker: TBN
Moderator: Cammie M Symonowicz
Facilitator: TBN

Speaker and description will be available after the Award Selection Committee selects the Nathan Brewer Recipient in July 2017.

This Special Topic Lecture is sponsored in part by AALAS Awards Selection Committee (ASC).

Wednesday Afternoon

Panel Discussions

Continuous Improvements and Innovations in Laboratory Animal Welfare
12:30 PM - 2:00 PM/Room: 12B
Leader: Letty V Medina
Moderator: Kelsey A Lin
Facilitator: Donna J Strasburg
Panelist: Carey M Allen, Brian J Ebert, Chris L Medina, Letty V Medina

AbbVie is committed to providing the highest quality of care to our research animals. To accomplish this, we work hard to maintain high standards of animal care and use, and we continuously look for innovative ways to improve our programs. Our Comparative Medicine department includes husbandry/operations, veterinary services, and research/surgical services groups. These groups work closely to support all animal research staff and collaborate often with the Global Animal Welfare team, including the Alternatives Committee, to adopt enhancements to our animal care and use program. Participants will learn about a variety of innovative management and care practices that enhance laboratory animal welfare. These practices include examples of enrichment and operant conditioning, husbandry improvements, management tools to support better animal care oversight, as well as a practical way to highlight progress in adoption of the 3Rs. The panelists will emphasize how these various efforts were implemented primarily through the inventive ideas of the staff who are dedicated to a continuous improvement process. Developing a culture of continuous improvement ensures we are making steady progress rather than sliding backwards. These ongoing efforts to imagine, invent, improve, and inspire better animal care create a culture of continuous improvement that is both rewarding and optimal to maintaining a high quality animal care program.

This Panel Discussion is sponsored in part by AbbVie, Inc.

Preparing the Next Generation of Laboratory Animal Veterinarians: Strategies and Challenges in ACLAM-Recognized Training Programs
12:30 PM - 2:00 PM/Room: 19A
Leader/Moderator: Julie Watson
Facilitator: Kinta J Diven
Panelist: Richard E Fish, Megan H Nowland, Peter C Smith, Douglas K Taylor

The 48 ACLAM-recognized residency training programs in laboratory animal medicine are incredibly varied in size, structure, and types of clinical, didactic, and research experience offered. Participants in this panel discussion represent a cross-section of available programs. They will discuss how they approach meeting required training program standards and describe facets of their programs that work particularly well, as well as those that present challenges. Topics to be discussed include what kind of candidates are a good fit, methods of recruitment, provisions of acclimation/orientation and individual or peer mentoring, degree of resident supervision/independence, program length and structure, communication issues, how research and pathology experience is provided, and whether the program provides help with writing CVs and finding jobs. Participants will also discuss the impact of T32 funded research training on LAM programs, and the desirability of incorporating specific training in business management, supervisory skills, and manuscript writing into their programs. Last, we will discuss whether faculty who participate in training programs should have specific training in curriculum design and student assessment. This discussion will be of interest to everyone in the LAM community and should be helpful in generating ideas to improve training programs.

The Internet of Things in Laboratory Animal Operations
12:30 PM - 2:00 PM/Room: 17B
Leader: Pam A Straeter
Moderator: Melissa A Hostrander
Facilitator: Joanne C Drew
Panelist: Susie Chow, Kevin Gift, John J Sancenito, Pam A Straeter

The “Internet of Things," according to Webopedia, is defined as a network of physical objects with internet connectivity that communicate with each other and other internet-enabled systems. In the age where technology and smart devices intersect and enhance our personal lives, the world of laboratory animal operations has followed suit. With equipment RFID, security webcams, remote environmental monitoring systems, and so much more, the convenience of being connected 24 hours a day, 365 days a year, one has to wonder how far is too far? As the technology is refined and advanced, these systems continue to take control over our surroundings so much so that we may lose some ability to secure the information. Where is our industry’s vulnerability as we continue to embrace technology that will assist us in controlling and organizing our operations? In this panel discussion, we will explore the advantages and risks that internet-enabled systems present and provide participating laboratory animal management personnel the opportunity to examine and discuss the exposed spaces needed to balance operational effectiveness and efficiencies while ensuring security and safeguarding valuable animals and research.

What's in Your Facility? Consideration of Extrinsic Environmental Factors to Improve and Inspire Reproducibility in Animal Research
12:30 PM - 2:00 PM/Room: 16A
Leader/Moderator: Malgorzata Klosek
Facilitator: Stephanie Murphy
Panelist: Cory Brayton, Samuel Cartner, Robert Dauchy, Bonnie Hylander, Randal Voss

There is concern within the animal research community that extrinsic environmental factors, like lighting, temperature, caging, and housing-related issues affect study outcomes. The full biological ramifications of such factors are not well understood, but there is growing recognition that to accurately describe any experimental set up, it is necessary to provide information about the environmental conditions in which an animal was generated, raised, and housed. This panel will address current knowledge and practices regarding monitoring of extrinsic environmental factors, accounting for them in the experimental design, identifying their influences on research results, and sharing such information with other researchers to enhance reproducibility in animal research. Panelists include researchers, editors, editorial board members, veterinarians, resource directors, lab managers, and health scientist administrators. The panel will engage members of the laboratory animal science community to share their views on priorities on addressing these issues, particularly with regards to specific animal species, scientific thematic areas, experimental approaches, and the most dominant extrinsic environmental factors. Participants will learn about the current practices and existing tools on how to collect, summarize, and share extrinsic environmental data; the need for community-derived guidelines on environmental data collection, extraction, and sharing in connection to best practices for animal facility management; experimental study conduct; interpretation and application of research findings; and the challenges associated with community consensus on data content and formats, and wider acceptance and use of such guidelines, including a unified content of such data in publications. The target audience includes all individuals engaged in research involving animal models, including animal facility managers; lab animal and research technicians; veterinarians; IACUC members; scientists from academia, industry, and government; and editors, reviewers, and authors.


W-17 Achieving Cultural Competency in Global Laboratory Animal Science
1:00 PM - 5:00 PM/Room: 5A
Leaders/Faculty: Tiffany L Whitcomb, LaTesa J Hughes
Facilitator: Jodi A Scholz
Workshop Fee: $140 Workshop Limit: 50

Modern information technology capabilities, increased availability of international travel, and recent drives for global harmonization of research practices make interfacing among researchers and animal care and use personnel of diverse cultural backgrounds more likely and more feasible than ever before. While diversity is critical for an institution’s ability to innovate and adapt in a fast-changing environment, it presents a unique challenge to achieve standards in animal research and care. Foremost of these challenges is the language and communication barrier that can lead to misunderstandings, ineffectiveness of training and education, and noncompliance issues. Other examples include religious beliefs and cultural and societal mores that can challenge a personnel’s ability to perform necessary job duties. This workshop aims to help participants gain a different perspective and achieve competency in global laboratory animal science by actively engaging them in various activities. The session will open with an exercise that challenges participants to critically evaluate common myths and facts in recent publications. Another activity involves a language-learning exercise to promote cultural empathy and understanding. Participants will also have opportunities to explore common workplace challenges rooted in differences in culture through small group discussion. Valuable resources for learning about other cultures and languages will be shared. The workshop is appropriate for all attendees, including veterinarians, IACUC members, compliance and training officers, animal care staff, and human resource personnel. By the end of the session participants will be able to challenge their beliefs about diversity in the workplace by exploring common myths and facts in recent publications, build on empathy generated during a language-learning exercise to refine skills for working with personnel when a language barrier exists, connect their prior experiences in the workplace to common personnel interactions described in situational vignettes, and apply key cultural competencies to predict improved personnel management strategies as a result of discussing vignettes.

W-18 Emergency Preparedness and Disaster Planning: Does Your Facility Plan Harmonize with the Local, State, and Federal Responses to an Emergency or Disaster?
1:00 PM - 5:00 PM/Room: 8B
Leaders: William G Greer and Ron E Banks
Faculty: Carol L Clarke, William G Greer, Jeanie Lin, Julie Marshall, Anne McCann, Erin Ribka, Gordon S Roble
Facilitator: William G Greer
Workshop Fee: $140 Workshop Limit: 50

The IACUC Administrator’s Association (IAA) facilitates opportunities for IACUC professionals to share successful processes and ideas, especially through best practice meetings to discuss emerging problems, and works collaboratively with the USDA, OLAW, and AAALAC. The purpose of this panel meeting is to begin the discussion on non-regulatory best practices for emergency management and disaster planning for research facilities in the context of harmonization with the local, state, and federal response to adverse events. This program will be based on a model already established by U.S. zoos that was facilitated through the USDA. The goal would be to begin the process for establishing a similar resource for the animal research community. The target audience is everyone involved in the animal care and use community. Every member of the community is responsible for health and wellbeing of research and teaching animals. This topic will give each the opportunity to learn about disaster planning and provide input from their point of view and based on their specialty.

This Workshop is sponsored in part by USDA and the IACUC Administrators Association.

W-19 Introduction to Acupuncture in Laboratory Animal Medicine
1:00 PM - 5:00 PM/Room: 7
Leader: Harvey E Ramirez
Faculty: Alan G Brady, Stephanie J Buchl, Patty Chen, Elizabeth R Magden
Facilitator: Jennifer L Asher
Workshop Fee: $140 Workshop Limit: 25

Acupuncture is an ancient therapeutic technique that involves the insertion of sterile needles into defined sites on the body in order to stimulate physiologic balance through neural signaling. It is one of the most recognized and scientifically validated complementary modalities used in veterinary medicine, and its use has dramatically broadened the scope of what should be considered high-standard veterinary care. The research supporting the use of acupuncture demands that laboratory animal veterinarians cultivate a progressive mindset regarding alternative and complementary treatment modalities and their implementation in laboratory animal care. In this workshop, participants will receive a historical perspective of acupuncture and traditional Chinese veterinary medicine, be provided with an indepth understanding of the neurobiological and neurophysiological mechanism of acupuncture treatment, learn to locate the most commonly used acupuncture points in laboratory animal medicine, learn basic techniques used when placing needles, and learn indications and contraindications for dry needling, aquapuncture, and electro-acupuncture. The target audience includes veterinarians with an interest in learning acupuncture with the goal of integrating it into their clinical care of laboratory animals.

This Workshop is sponsored in part by Chi Institute of Traditional Chinese Veterinary Medicine.

W-20 Teaching Monkeys to Cooperate with Restraint: Using Positive Reinforcement Training and Temperament Testing Methods
(8-hour workshop continued on Thursday 8:00 AM)
1:00 PM - 5:00 PM/Room: 10B
Leader: Jaine E Perlman
Faculty: Mollie A Bloomsmith, Kris Coleman, Jennifer L McMillan
Facilitator: Mark J Prescott
Workshop Fee: $250 Workshop Limit: 50

The workshop includes 8-hours of instruction using positive reinforcement training (PRT) to teach monkeys to cooperate with various restraint procedures, as well provide information about using temperament testing to assist in selection of subjects and planning for their training. Participants will learn approaches to training laboratory primates to cooperate with restraint for sample collection (e.g., blood, vaginal fluids) and administration (e.g., injections) and for chair restraint. PRT is an important refinement in the care of nonhuman primates and an effective means of improving their welfare. However, animals respond differently to restraint, and measuring temperament provides insight into how individuals might respond to these procedures, allowing for individualized and more effective training plans. Goals include introducing participants to animal training terminology and techniques; teaching PRT techniques as they apply to restraint procedures, such as the use of the cage squeeze back mechanism and chair restraint; and teaching methods to assess and quantify temperament in monkeys and to use this information to develop individualized training plans. Participants will also learn to incorporate alternative techniques, such as negative reinforcement to meet research timelines. Participants will learn how to shape behavior and apply desensitization techniques, how to maintain trained behaviors over time, and how to transfer trained behaviors among multiple staff members. Participants will learn how temperament can impact training approaches and the anticipated timelines for training to cooperate with restraint. Understanding the intersection of individual differences in temperament and animal training will aid in the design of more efficient animal training programs. This workshop is designed for those experienced in working with primates, including behavior specialists, animal caregivers, research technicians, animal managers, veterinarians, and investigators.

This Workshop is sponsored in part by Hybex Innovations, Lomir Biomedical Inc., NC3Rs, and Unifab Corporation.

W-21 The Art of the Perfect Presentation
1:00 PM - 5:00 PM/Room: 8C
Leader: Christal Huber
Faculty: William Singleton
Facilitator: Temeri Wilder-Kofie
Workshop Fee: $140 Workshop Limit: 50

Giving a great presentation is no simple accomplishment. It takes time and a lot of effort to learn how to give good presentations. Perfection is a relative term, yet we all attempt to improve our delivery with each presentation. Often the anxiety associated with public speaking is significant enough to negate any amount of preparation. It’s been said that people in general, fear public speaking over any other fear. In this session we will look at some critical factors to help your presentation be as perfect as possible while eliminating some of the associated anxiety. Special emphasis will be place on the power of practice and the importance of preparation. Opportunity will be provided in this session to learn how to practice. We will discuss the impact of finding the right mode for delivering content, whether that is commonly used power points or incorporating the use of handouts and audience participation. More and more research is confirming the use of active learning strategies to maximize engagement and learning. The idea that people learn best when lectured to is just no longer true. This session will introduce various active learning strategies that can be incorporated into a 15 minute presentation or a 4 hour workshop. And finally we will provide metrics to help you know if your presentations meet your intended objectives. At the conclusion of the session, attendees will have a better understanding of how to use the tools and skills necessary to deliver a memorable and great presentation. This session will be ideal for any one that wants to improve their public speaking skills. From the novice to the experience speaker, this session will introduce tools, activities and ideas anyone will be able to practice and perfect to deliver perfect presentations.


Challenges and Opportunities in Support of Interinstitutional Collaborations: Are You Prepared?
2:45 PM - 5:00 PM/Room: 9B
Leader: Betty R Theriault
Moderator: Nicolette A Zielinski Mozny
Facilitator: Christina M Olivares

The interdisciplinary landscape of 21st century biomedical research is presenting new challenges for the laboratory animal community in support of intra and inter-institutional collaborations. Such collaborations arise not only from synergistic relationships resulting from intellectual collaborations, but also through the desire to transform individual research programs beyond the scope of what a given institution may have resources or capacity to support. Many institutions have developed scientific and/or medical centers and institutes of excellence by assembling top researchers and physicians in specialized areas of expertise. In doing so, highly specialized as well as costly technology may be acquired to support these local, regional, or national centers of excellence which may not be readily available more broadly due to limited financial resources or individualized expertise in a given field. To capitalize on these limited technical and intellectual resources, many researchers are extending the scope of their programs to include interinstitutional collaborations which may encompass academia to academia, academia to industry, or visiting scientist arrangements to achieve their scientific goals. In this seminar, we will explore examples of inter-institutional collaborations and discuss some of the many critical components necessary for their success. Participants will learn the current climate pressures which are fostering inter-institutional collaboration interests. Regulatory requirements and considerations for institutions, IACUCs, and individuals engaged in collaborative studies will be outlined and discussed. Consideration of regulations, animal and colony health status, timing, and the practical procedures for sharing animal model resources will be summarized. The seminar is directed to research scientists, veterinarians, program directors, operations specialists, shipping coordinators, IACUC members, compliance officers, and program administrators.


2:45 Betty R TheriaultWelcome and Introduction
3:00 Betty R Theriault Animal Model Collaborations: Considerations in Facilitating Resource Sharing
3:20 Nicolette A Zielinski Mozny Grant Based Collaborations: How Does Your Institution Collaborate?
3:50 Marcy A Brown Outsourcing Studies: Managing Risk while Advancing Research
4:20 Ann Schue Import/Export Considerations for Collaborative Studies between Institutions

Emerging and Re-Emerging Infectious Agents of Laboratory Rodents
2:45 PM - 5:00 PM/Room: Ballroom D
Leader/Moderator: Robert S (Bob) Livingston
Facilitator: Kayla Johnson

Infectious diseases have been emerging and re-emerging since the beginning of time. In laboratory animal facilities, emerging and re-emerging infectious agents present an ongoing threat. With the increase in the use of immunocompromised animal models, we have seen the emergence of several previously unrecognized pathogens. In this seminar, information about two newly recognized rodent pathogens will be presented: rat polyomavirus 2 (RPyV2) and a novel Corynebacterium species. Presentations will describe disease manifestations, identification and characterization of the pathogens, diagnosis, prevalence, and elimination of the organism. And, as if we didn’t have enough to worry about, there has been a recent outbreak of Seoul virus in pet rats that has raised concerns as to the potential for this virus to re-emerge in our animal facilities. The last presentation will discuss CDC’s investigation of the Seoul virus outbreak and the resulting human infections. The target audience is laboratory animal veterinarians, facility managers, study directors, and technical specialists who manage animal health programs. The goal of the seminar is to heighten awareness of newly recognized infectious diseases that affect immunocompromised rodent models commonly used for cancer and transplant organ investigations.


2:45 Robert S Livingston Welcome and Introduction
2:55 Cynthia L Besch-Williford Identification and Characterization of Rat Polyomavirus 2
3:25 Megan L Lambert Impact of Rat Polyomavirus 2 Infection on a Rat Breeding Colony
3:35 Joseph T Newsome Rederivation to Eliminate the Rat Polyomavirus 2 Infection and Potential Impact on Research
4:00 Marcus J Crim A Novel Corynebacterium Species Infecting Immunodeficient Mice
4:20 Matthew H Myles Update on the Recent Outbreak of Seoul Virus in Pet Rats
4:40 Robert S Livingston Summary

Staffing and Working in a High-Containment Environment
2:45 PM - 5:00 PM/Room: Ballroom F
Leader: George W Lathrop
Moderator: Rex Howard
Facilitator: Patrick O Mills

Performing animal research within high containment laboratories presents unique challenges for facility managers, PIs, veterinary staff, and animal caretakers. Speakers will present a general overview of the challenges that working within a high containment facility (HCL) entails, along with a framework for evaluating whether pursuing the construction of a HCL is economically feasible. Optimizing facility resources, managing equitable allocations, achieving education compliance, managing training efforts, and assuring adequate learning exposures will also be discussed. The regulatory requirements for work with USDA-covered species will be introduced, along with the ADDIE (Analysis, Design, Development, Implementation, Evaluation) model of instructional program design. After this seminar, participants will be able to estimate and evaluate the costs associated with staffing and operating a high containment laboratory, develop protocols to train staff and investigators in high containment work, select animals for use within high containment labs, and return to their facility with the tools necessary to design a mock HCL for personnel training. This discussion will be valuable to attendees with a variety of backgrounds, including veterinarians, behavioral specialists, veterinary technicians, facility managers, and animal care providers.


2:45 Rex Howard Welcome and Introduction
2:55 Cassandra M Tansey Animal Selection for High Containment Work
3:15 Sarah Genzer Return on Investment in High Containment Laboratories
3:45 April Clayton Planning and Developing a Mock HCL
4:05 Brianna Skinner Steps in Developing Training Protocols

Tools for Developing a Stimulating and Cooperative Environment for Laboratory Minipigs
2:45 PM - 5:00 PM/Room: 18B
Leader: Nicole Navratil
Moderator: Kirsten R Jacobsen, Michelle L Salerno
Facilitator: Pam Huber

The complexity of swine cognition should not be underestimated in the laboratory. When developing behavioral management and husbandry procedures for laboratory minipigs, it is important to remember that minipigs are highly intelligent with a unique perspective about their environment. This intelligence can cause a challenge to providing stimulating environments, but it can also provide a benefit as minipigs can be trained to participate in study procedures. This seminar will review ways in which minipigs may experience their environment, how to evaluate and mitigate stress, as well as ways to help enhance environmental stimulation. This seminar is valuable for technicians, veterinarians, and managers who work directly with minipigs in their laboratory facilities.


2:45 Nicole Navratil Welcome and Introductions
2:50 Kirsten R Jacobsen Introduction to Swine Behavioral Management
3:15 Carolyn M Allen Providing Cognitively Stimulating Enrichment for Laboratory Swine
3:40 Felipe Berard Evaluation of Stress and Acclimation to New Environments, Procedures, or Equipment
4:05 Michelle L Salerno Mutual Cooperation and Training Minipigs for Blood Collection and Other Procedures

This Seminar is sponsored in part by Marshall BioResources and Ellegaard Gottingen Minipigs.