Microbiota of Laboratory Animals: An Emerging Frontier (Webinar Recording)
WEB-038A: The gut microbiota (GM) is the community of commensal microorganisms that occupy the intestinal tracts of animal species. Interest in GM has exploded due to advancement and availability of technologies to define and analyze these complex populations (complex gnotobiology). Studies on complex GM focus on intestinal disease as well as physiological processes such as neurodevelopment and behavior. GM differences in contemporary rodent colonies can be exploited through procedures such as complex microbiota targeted rederivation (CMTR). In this webinar, we will discuss the impact of CMTR and review the data that show how diverse, naturally occurring GM profiles significantly influence lesion score severity in a mouse model of inflammatory bowel disease and tumor burden in rat and mouse models of colorectal cancer. Finally, we will discuss the development of and applications for mouse colonies with standardized complex GM. These colonies will be valuable for addressing mechanisms by which GM influence model phenotypes with the ultimate goal of refining models towards optimal reproducibility and translatability.
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